Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYates, Paul A-
dc.contributor.authorSirisriro, R-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorFarquharson, Shawna-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.identifier.citationNeurology 2011; 77(1): 48-54en
dc.description.abstractIncidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with β-amyloid (Aβ) deposition using (11)C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and (11)C-PiB PET. (11)C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6-33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03-1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.Asymptomatic Aβ deposition in older adults is strongly associated with LMH.en
dc.subject.otherAged, 80 and overen
dc.subject.otherAlzheimer Disease.genetics.pathology.radionuclide imagingen
dc.subject.otherAmyloid beta-Peptides.metabolismen
dc.subject.otherApolipoprotein E4.geneticsen
dc.subject.otherBenzothiazoles.diagnostic useen
dc.subject.otherBrain.metabolism.radionuclide imagingen
dc.subject.otherBrain Mappingen
dc.subject.otherCarbon Radioisotopes.diagnostic useen
dc.subject.otherCerebral Hemorrhage.etiologyen
dc.subject.otherCognition Disorders.genetics.pathology.radionuclide imagingen
dc.subject.otherLogistic Modelsen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherNerve Fibers, Myelinated.pathology.radionuclide imagingen
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherPsychiatric Status Rating Scalesen
dc.titleCerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.en
dc.typeJournal Articleen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.contributor.corpauthorAIBL Research Groupen
dc.type.austinJournal Articleen, Shawna
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.cerifentitytypePublications- Care- Medicine- Imaging and Therapy- Florey Institute of Neuroscience and Mental Health- Florey Institute of Neuroscience and Mental Health- Imaging and Therapy-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Feb 22, 2024

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.