Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/11291
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dc.contributor.authorYates, Paul A-
dc.contributor.authorSirisriro, R-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorFarquharson, Shawna-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorRowe, Christopher C-
dc.date.accessioned2015-05-16T00:52:49Z
dc.date.available2015-05-16T00:52:49Z
dc.date.issued2011-06-22-
dc.identifier.citationNeurology 2011; 77(1): 48-54en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/11291en
dc.description.abstractIncidental cerebral microhemorrhage (MH) is frequently found in older individuals scanned with susceptibility-weighted MRI (SWI) or gradient-recalled echo MRI. MH have been linked with β-amyloid (Aβ) deposition using (11)C-Pittsburgh compound B (PiB) PET in Alzheimer disease (AD) and cerebral amyloid angiopathy (CAA). We hypothesized that Aβ deposition in asymptomatic elderly individuals is associated with lobar MH (LMH).This was a cross-sectional study of 84 elderly healthy controls (HC), 28 subjects with mild cognitive impairment (MCI), and 26 subjects with probable AD who underwent 3-T SWI and (11)C-PiB PET. (11)C-PiB cortical binding was quantified normalized to cerebellar cortex (standardized uptake value ratio [SUVR]) and scans classified as positive (PiB+) or negative (PiB-) by visual inspection. MH were manually counted and categorized by region and as lobar or nonlobar.LMH were present in 30.8% of AD, 35.7% of MCI, and 19.1% of HC. The prevalence of LMH among PiB+ subjects was similar, regardless of clinical classification (AD 30.8%, MCI 38.9%, HC 41.4%, p > 0.7). HC with LMH had significantly higher mean neocortical SUVR (1.7 ± 0.5) than HC without LMH (1.3 ± 0.3, p ± 0.01). In HC, there was a positive correlation between number of LMH and SUVR, and between LMH and age. In HC, PiB+ (odds ratio [OR] 7.3, 95% confidence interval [CI] 1.6-33.7, p = 0.01) and age (OR 1.2, 95% CI 1.03-1.3, p = 0.02) both independently predicted the occurrence of LMH using logistic regression.Asymptomatic Aβ deposition in older adults is strongly associated with LMH.en
dc.language.isoenen
dc.subject.otherAgeden
dc.subject.otherAged, 80 and overen
dc.subject.otherAging.pathologyen
dc.subject.otherAlzheimer Disease.genetics.pathology.radionuclide imagingen
dc.subject.otherAmyloid beta-Peptides.metabolismen
dc.subject.otherApolipoprotein E4.geneticsen
dc.subject.otherBenzothiazoles.diagnostic useen
dc.subject.otherBrain.metabolism.radionuclide imagingen
dc.subject.otherBrain Mappingen
dc.subject.otherCarbon Radioisotopes.diagnostic useen
dc.subject.otherCerebral Hemorrhage.etiologyen
dc.subject.otherCognition Disorders.genetics.pathology.radionuclide imagingen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLogistic Modelsen
dc.subject.otherMagnetic Resonance Imaging.methodsen
dc.subject.otherMaleen
dc.subject.otherNerve Fibers, Myelinated.pathology.radionuclide imagingen
dc.subject.otherPositron-Emission Tomography.methodsen
dc.subject.otherPsychiatric Status Rating Scalesen
dc.titleCerebral microhemorrhage and brain β-amyloid in aging and Alzheimer disease.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationDepartment of Nuclear Medicine and Centre for PET, Austin Health, 145 Studley Road, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1212/WNL.0b013e318221ad36en
dc.description.pages48-54en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/21700585en
dc.contributor.corpauthorAIBL Research Groupen
dc.type.contentTexten
dc.type.austinJournal Articleen
local.name.researcherFarquharson, Shawna
item.fulltextNo Fulltext-
item.languageiso639-1en-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptAged Care-
crisitem.author.deptGeriatric Medicine-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
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