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Title: Arsenic trioxide associated toothache.
Austin Authors: Siderov, Jim ;Duggan, John
Affiliation: Cancer Services, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 12-Jun-2009
Publication information: Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners 2009; 16(2): 127-8
Abstract: Arsenic trioxide in the treatment of acute promyelocytic leukaemia is relatively safe with minimal side effects. Dental toxicities associated with its use are uncommon. We describe the first case report of toothache associated with arsenic trioxide. A 45-year-old male with relapsed APL was commenced on a treatment schedule of all-trans-retinoic acid 20mg four times a day for 14 days concurrent with a 10mg intravenous infusion of arsenic trioxide for 28 days. After 14 doses of the 6th cycle of treatment he experienced severe acute pain in various parts of the oral cavity. Extensive examination including an orthodontic review concluded there was no indication that the pain symptoms were due to a dental or endodontic cause. Four days after completing his 6th cycle the pain completely resolved. The mechanism of this adverse event remains unclear. Physicians with patients receiving arsenic trioxide with unexplained toothache should consider the arsenic as the cause of the pain.
Gov't Doc #: 19525303
DOI: 10.1177/1078155209338727
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners
Type: Journal Article
Subjects: Arsenicals.administration & dosage.adverse effects
Infusions, Intravenous
Leukemia, Promyelocytic, Acute.drug therapy
Middle Aged
Oxides.administration & dosage.adverse effects
Toothache.chemically induced.diagnosis
Tretinoin.administration & dosage
Appears in Collections:Journal articles

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