Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSiderov, Jimen
dc.contributor.authorDuggan, Johnen
dc.identifier.citationJournal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners 2009; 16(2): 127-8en
dc.description.abstractArsenic trioxide in the treatment of acute promyelocytic leukaemia is relatively safe with minimal side effects. Dental toxicities associated with its use are uncommon. We describe the first case report of toothache associated with arsenic trioxide. A 45-year-old male with relapsed APL was commenced on a treatment schedule of all-trans-retinoic acid 20mg four times a day for 14 days concurrent with a 10mg intravenous infusion of arsenic trioxide for 28 days. After 14 doses of the 6th cycle of treatment he experienced severe acute pain in various parts of the oral cavity. Extensive examination including an orthodontic review concluded there was no indication that the pain symptoms were due to a dental or endodontic cause. Four days after completing his 6th cycle the pain completely resolved. The mechanism of this adverse event remains unclear. Physicians with patients receiving arsenic trioxide with unexplained toothache should consider the arsenic as the cause of the pain.en
dc.subject.otherArsenicals.administration & dosage.adverse effectsen
dc.subject.otherInfusions, Intravenousen
dc.subject.otherLeukemia, Promyelocytic, Acute.drug therapyen
dc.subject.otherMiddle Ageden
dc.subject.otherOxides.administration & dosage.adverse effectsen
dc.subject.otherToothache.chemically induced.diagnosisen
dc.subject.otherTretinoin.administration & dosageen
dc.titleArsenic trioxide associated toothache.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitionersen
dc.identifier.affiliationCancer Services, Austin Health, Heidelberg, Victoria, Australiaen
dc.type.austinJournal Articleen
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.cerifentitytypePublications- Newton-John Cancer Wellness and Research Centre-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

checked on Feb 6, 2023

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.