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Title: Event-related fMRI of myoclonic jerks arising from dysplastic cortex.
Austin Authors: Archer, John S ;Waites, Anthony B;Abbott, David F ;Federico, Paolo;Jackson, Graeme D 
Affiliation: Brain Research Institute, Health, Austin, Victoria, Australia
Issue Date: 1-Sep-2006
Publication information: Epilepsia; 47(9): 1487-92
Abstract: Malformations of cortical development can cause epileptiform activity and myoclonic jerks, yet EEG correlates of jerks can be difficult to obtain.We studied a woman who had frequent episodes of persistent right-foot jerking since childhood. Ictal and interictal EEG had shown no localizing epileptiform activity. Functional imaging experiments were performed with concurrent video monitoring to document the timing of foot jerks. These studies mapped brain regions controlling voluntary right- and left-foot movements, and spontaneous right-foot jerks.High-resolution structural MR imaging revealed a dysplastic gyrus extending anteriorly off the left central sulcus. Event-related analysis of spontaneous jerks revealed prominent activation of the left precentral gyrus (right-foot motor area), bilateral medial frontal regions (supplementary motor area), and the dysplastic gyrus. Hemodynamic response modeling to foot jerks revealed the hemodynamic response peaked earlier in the dysplastic cortex and SMA regions than in the foot area.Event-related fMRI in a patient with spontaneous and induced epileptic foot jerks revealed brain regions active during jerks. The results of this analysis allowed us to tailor subsequent intracerebral recordings. Analysis of the timing of the hemodynamic response showed certain brain regions with an earlier rise in BOLD signal, suggesting a possible initiating role, or different hemodynamic response functions. Hemodynamic response timing should be considered carefully when interpreting event-related studies of epileptiform activity.
Gov't Doc #: 16981864
DOI: 10.1111/j.1528-1167.2006.00620.x
Journal: Epilepsia
Type: Journal Article
Subjects: Adult
Brain Mapping
Cerebral Cortex.abnormalities.physiopathology
Electroencephalography.statistics & numerical data
Epilepsies, Myoclonic.diagnosis.physiopathology
Evoked Potentials.physiology
Functional Laterality.physiology
Magnetic Resonance Imaging.statistics & numerical data
Monitoring, Intraoperative.statistics & numerical data
Motor Cortex.physiopathology
Movement Disorders.diagnosis.physiopathology
Neural Pathways.physiopathology
Videotape Recording
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