Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/10236
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dc.contributor.authorArcher, John Sen
dc.contributor.authorWaites, Anthony Ben
dc.contributor.authorAbbott, David Fen
dc.contributor.authorFederico, Paoloen
dc.contributor.authorJackson, Graeme Den
dc.date.accessioned2015-05-15T23:37:19Z
dc.date.available2015-05-15T23:37:19Z
dc.date.issued2006-09-01en
dc.identifier.citationEpilepsia; 47(9): 1487-92en
dc.identifier.govdoc16981864en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/10236en
dc.description.abstractMalformations of cortical development can cause epileptiform activity and myoclonic jerks, yet EEG correlates of jerks can be difficult to obtain.We studied a woman who had frequent episodes of persistent right-foot jerking since childhood. Ictal and interictal EEG had shown no localizing epileptiform activity. Functional imaging experiments were performed with concurrent video monitoring to document the timing of foot jerks. These studies mapped brain regions controlling voluntary right- and left-foot movements, and spontaneous right-foot jerks.High-resolution structural MR imaging revealed a dysplastic gyrus extending anteriorly off the left central sulcus. Event-related analysis of spontaneous jerks revealed prominent activation of the left precentral gyrus (right-foot motor area), bilateral medial frontal regions (supplementary motor area), and the dysplastic gyrus. Hemodynamic response modeling to foot jerks revealed the hemodynamic response peaked earlier in the dysplastic cortex and SMA regions than in the foot area.Event-related fMRI in a patient with spontaneous and induced epileptic foot jerks revealed brain regions active during jerks. The results of this analysis allowed us to tailor subsequent intracerebral recordings. Analysis of the timing of the hemodynamic response showed certain brain regions with an earlier rise in BOLD signal, suggesting a possible initiating role, or different hemodynamic response functions. Hemodynamic response timing should be considered carefully when interpreting event-related studies of epileptiform activity.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherBrain Mappingen
dc.subject.otherCerebral Cortex.abnormalities.physiopathologyen
dc.subject.otherElectroencephalography.statistics & numerical dataen
dc.subject.otherEpilepsies, Myoclonic.diagnosis.physiopathologyen
dc.subject.otherEvoked Potentials.physiologyen
dc.subject.otherFemaleen
dc.subject.otherFoot.innervation.physiopathologyen
dc.subject.otherFunctional Laterality.physiologyen
dc.subject.otherHumansen
dc.subject.otherMagnetic Resonance Imaging.statistics & numerical dataen
dc.subject.otherMonitoring, Intraoperative.statistics & numerical dataen
dc.subject.otherMotor Cortex.physiopathologyen
dc.subject.otherMovement Disorders.diagnosis.physiopathologyen
dc.subject.otherNeural Pathways.physiopathologyen
dc.subject.otherOxygen.blooden
dc.subject.otherVideotape Recordingen
dc.titleEvent-related fMRI of myoclonic jerks arising from dysplastic cortex.en
dc.typeJournal Articleen
dc.identifier.journaltitleEpilepsiaen
dc.identifier.affiliationBrain Research Institute, Health, Austin, Victoria, Australiaen
dc.identifier.doi10.1111/j.1528-1167.2006.00620.xen
dc.description.pages1487-92en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/16981864en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
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