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Title: Low doses of lithium carbonate reduce melatonin light sensitivity in healthy volunteers.
Austin Authors: Hallam, Karen T;Olver, James S ;Horgan, Jennifer E;McGrath, Caroline;Norman, Trevor R 
Affiliation: Department of Psychiatry, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
Issue Date: 1-Jun-2005
Publication information: The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (cinp); 8(2): 255-9
Abstract: Sensitivity of the pineal hormone melatonin to bright light at night has been posited as a putative marker of affective disorders. Research demonstrates melatonin supersensitivity to light in bipolar disorder, however the role that lithium carbonate plays in this response is unclear. This study assessed the effect of lithium on nocturnal melatonin secretion and sensitivity to light in healthy adults. Ten participants, tested on two nights, had blood samples drawn between 20:00 and 02:30 hours. On testing nights participants were exposed to 200 lux of light between 24:00 and 01:00 hours. Participants took 250 mg of lithium daily for 5 d between testing nights. The results indicated that lithium had a significant effect on sensitivity to light but not on overall melatonin synthesis. This finding has implications on the true magnitude of the melatonin light response in people with bipolar disorder and may elucidate possible mechanisms of action of lithium.
Gov't Doc #: 15850501
DOI: 10.1017/S1461145704004894
Type: Journal Article
Subjects: Adult
Antimanic Agents.administration & dosage
Area Under Curve
Circadian Rhythm.drug effects
Lithium Carbonate.administration & dosage
Melatonin.adverse effects.secretion
Photic Stimulation.methods
Photophobia.chemically induced.drug therapy
Appears in Collections:Journal articles

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