Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9906
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dc.contributor.authorHallam, Karen Ten
dc.contributor.authorOlver, James Sen
dc.contributor.authorHorgan, Jennifer Een
dc.contributor.authorMcGrath, Carolineen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T23:11:15Z
dc.date.available2015-05-15T23:11:15Z
dc.date.issued2005-06-01en
dc.identifier.citationThe International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (cinp); 8(2): 255-9en
dc.identifier.govdoc15850501en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9906en
dc.description.abstractSensitivity of the pineal hormone melatonin to bright light at night has been posited as a putative marker of affective disorders. Research demonstrates melatonin supersensitivity to light in bipolar disorder, however the role that lithium carbonate plays in this response is unclear. This study assessed the effect of lithium on nocturnal melatonin secretion and sensitivity to light in healthy adults. Ten participants, tested on two nights, had blood samples drawn between 20:00 and 02:30 hours. On testing nights participants were exposed to 200 lux of light between 24:00 and 01:00 hours. Participants took 250 mg of lithium daily for 5 d between testing nights. The results indicated that lithium had a significant effect on sensitivity to light but not on overall melatonin synthesis. This finding has implications on the true magnitude of the melatonin light response in people with bipolar disorder and may elucidate possible mechanisms of action of lithium.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAntimanic Agents.administration & dosageen
dc.subject.otherArea Under Curveen
dc.subject.otherCircadian Rhythm.drug effectsen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherLithium Carbonate.administration & dosageen
dc.subject.otherMaleen
dc.subject.otherMelatonin.adverse effects.secretionen
dc.subject.otherPhotic Stimulation.methodsen
dc.subject.otherPhotophobia.chemically induced.drug therapyen
dc.titleLow doses of lithium carbonate reduce melatonin light sensitivity in healthy volunteers.en
dc.typeJournal Articleen
dc.identifier.journaltitleThe international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)en
dc.identifier.affiliationDepartment of Psychiatry, The University of Melbourne, Austin Health, Heidelberg, Victoria, Australiaen
dc.identifier.doi10.1017/S1461145704004894en
dc.description.pages255-9en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15850501en
dc.type.austinJournal Articleen
local.name.researcherNorman, Trevor R
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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