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Title: TSH receptor protein is selectively expressed in normal human extraocular muscle.
Austin Authors: Kloprogge, Steven J;Busuttil, Bridget E;Frauman, Albert G 
Affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Jul-2005
Publication information: Muscle & Nerve; 32(1): 95-8
Abstract: Thyroid-associated ophthalmopathy is a common manifestation of Graves' disease. Its pathophysiology is not well understood but an antigen shared between the thyroid and orbit is thought to play a role. Using immunohistochemistry, we have demonstrated the presence of the autoantigenic target of Graves' disease, the thyroid-stimulating hormone receptor, in normal human extraocular muscle. These results support previous findings of the full length and splice variant thyroid-stimulating hormone receptor cDNA in extraocular muscle. The observation of the autoimmune target--the thyroid-stimulating hormone receptor protein--being shared between the thyroid and extraocular muscle lends greater support to the notion that an extraocular muscle thyroid-stimulating hormone receptor is also a likely target autoantigen in thyroid-associated ophthalmopathy.
Gov't Doc #: 15779008
DOI: 10.1002/mus.20315
Type: Journal Article
Subjects: Antibodies
Graves Disease.metabolism
Oculomotor Muscles.metabolism
Receptors, Thyrotropin.immunology.metabolism
Thyroid Gland.metabolism
Appears in Collections:Journal articles

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