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|Title:||TSH receptor protein is selectively expressed in normal human extraocular muscle.||Austin Authors:||Kloprogge, Steven J;Busuttil, Bridget E;Frauman, Albert G||Affiliation:||Clinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australia||Issue Date:||1-Jul-2005||Publication information:||Muscle & Nerve; 32(1): 95-8||Abstract:||Thyroid-associated ophthalmopathy is a common manifestation of Graves' disease. Its pathophysiology is not well understood but an antigen shared between the thyroid and orbit is thought to play a role. Using immunohistochemistry, we have demonstrated the presence of the autoantigenic target of Graves' disease, the thyroid-stimulating hormone receptor, in normal human extraocular muscle. These results support previous findings of the full length and splice variant thyroid-stimulating hormone receptor cDNA in extraocular muscle. The observation of the autoimmune target--the thyroid-stimulating hormone receptor protein--being shared between the thyroid and extraocular muscle lends greater support to the notion that an extraocular muscle thyroid-stimulating hormone receptor is also a likely target autoantigen in thyroid-associated ophthalmopathy.||Gov't Doc #:||15779008||URI:||http://ahro.austin.org.au/austinjspui/handle/1/9888||DOI:||10.1002/mus.20315||URL:||https://pubmed.ncbi.nlm.nih.gov/15779008||Type:||Journal Article||Subjects:||Antibodies
|Appears in Collections:||Journal articles|
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