Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9888
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dc.contributor.authorKloprogge, Steven Jen
dc.contributor.authorBusuttil, Bridget Een
dc.contributor.authorFrauman, Albert Gen
dc.date.accessioned2015-05-15T23:09:48Z
dc.date.available2015-05-15T23:09:48Z
dc.date.issued2005-07-01en
dc.identifier.citationMuscle & Nerve; 32(1): 95-8en
dc.identifier.govdoc15779008en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9888en
dc.description.abstractThyroid-associated ophthalmopathy is a common manifestation of Graves' disease. Its pathophysiology is not well understood but an antigen shared between the thyroid and orbit is thought to play a role. Using immunohistochemistry, we have demonstrated the presence of the autoantigenic target of Graves' disease, the thyroid-stimulating hormone receptor, in normal human extraocular muscle. These results support previous findings of the full length and splice variant thyroid-stimulating hormone receptor cDNA in extraocular muscle. The observation of the autoimmune target--the thyroid-stimulating hormone receptor protein--being shared between the thyroid and extraocular muscle lends greater support to the notion that an extraocular muscle thyroid-stimulating hormone receptor is also a likely target autoantigen in thyroid-associated ophthalmopathy.en
dc.language.isoenen
dc.subject.otherAntibodiesen
dc.subject.otherAutoantigens.metabolismen
dc.subject.otherGraves Disease.metabolismen
dc.subject.otherHumansen
dc.subject.otherImmunohistochemistryen
dc.subject.otherOculomotor Muscles.metabolismen
dc.subject.otherReceptors, Thyrotropin.immunology.metabolismen
dc.subject.otherThyroid Gland.metabolismen
dc.titleTSH receptor protein is selectively expressed in normal human extraocular muscle.en
dc.typeJournal Articleen
dc.identifier.journaltitleMuscle & nerveen
dc.identifier.affiliationClinical Pharmacology and Therapeutics Unit, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1002/mus.20315en
dc.description.pages95-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15779008en
dc.type.austinJournal Articleen
local.name.researcherFrauman, Albert G
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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