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Title: Epilepsy in twins: insights from unique historical data of William Lennox.
Austin Authors: Vadlamudi, L;Andermann, Eva;Lombroso, C T;Schachter, S C;Milne, R L;Hopper, John L;Andermann, Frederick;Berkovic, Samuel F 
Affiliation: Epilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg West, Victoria, Australia
Issue Date: 13-Apr-2004
Publication information: Neurology; 62(7): 1127-33
Abstract: To classify the Lennox twin pairs according to modern epilepsy classifications, use the classic twin model to identify which epilepsy syndromes have an inherited component, search for evidence of syndrome-specific genes, and compare concordances from Lennox's series with a contemporary Australian series.Following review of Lennox's original files describing twins with seizures from 1934 through 1958, the International League Against Epilepsy classifications of seizures and epileptic syndromes were applied to 169 pairs. Monozygous (MZ) and dizygous (DZ) pairs were subdivided into epilepsy syndromes and casewise concordances estimated.The authors excluded 26 pairs, with 71 MZ and 72 DZ pairs remaining. Seizure analysis demonstrated strong parallels between contemporary seizure classification and Lennox's terminology. Epilepsy syndrome diagnoses were made in 75%. The MZ and DZ casewise concordance estimates gave strong evidence for a major genetic influence in idiopathic generalized epilepsies (0.80 versus 0.00; n = 23). High MZ casewise concordances also supported a genetic etiology in symptomatic generalized epilepsies and febrile seizures. The pairs who were concordant for seizures usually had the same syndromic diagnoses in both twins (86% in MZ, 60% in DZ), suggesting syndrome-specific genes. Apart from partial epilepsies, the MZ casewise concordances were similar to those derived from Australian twin data.The authors were able to apply contemporary classifications to Lennox's twins. The data confirm genetic bases for common generalized epilepsies as well as febrile seizures and provide further support for syndrome-specific genes. Finally, comparable results to our Australian series were obtained, verifying the value of twin studies.
Gov't Doc #: 15079012
Type: Journal Article
Subjects: Adolescent
Age of Onset
Child, Preschool
Diseases in Twins.classification.diagnosis.genetics.history
History, 20th Century
Models, Statistical
Reproducibility of Results
Retrospective Studies
Terminology as Topic
Twins, Dizygotic.genetics
Twins, Monozygotic.genetics
Appears in Collections:Journal articles

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