Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9724
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dc.contributor.authorVadlamudi, Len
dc.contributor.authorAndermann, Evaen
dc.contributor.authorLombroso, C Ten
dc.contributor.authorSchachter, S Cen
dc.contributor.authorMilne, R Len
dc.contributor.authorHopper, John Len
dc.contributor.authorAndermann, Fredericken
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:55:22Z
dc.date.available2015-05-15T22:55:22Z
dc.date.issued2004-04-13en
dc.identifier.citationNeurology; 62(7): 1127-33en
dc.identifier.govdoc15079012en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9724en
dc.description.abstractTo classify the Lennox twin pairs according to modern epilepsy classifications, use the classic twin model to identify which epilepsy syndromes have an inherited component, search for evidence of syndrome-specific genes, and compare concordances from Lennox's series with a contemporary Australian series.Following review of Lennox's original files describing twins with seizures from 1934 through 1958, the International League Against Epilepsy classifications of seizures and epileptic syndromes were applied to 169 pairs. Monozygous (MZ) and dizygous (DZ) pairs were subdivided into epilepsy syndromes and casewise concordances estimated.The authors excluded 26 pairs, with 71 MZ and 72 DZ pairs remaining. Seizure analysis demonstrated strong parallels between contemporary seizure classification and Lennox's terminology. Epilepsy syndrome diagnoses were made in 75%. The MZ and DZ casewise concordance estimates gave strong evidence for a major genetic influence in idiopathic generalized epilepsies (0.80 versus 0.00; n = 23). High MZ casewise concordances also supported a genetic etiology in symptomatic generalized epilepsies and febrile seizures. The pairs who were concordant for seizures usually had the same syndromic diagnoses in both twins (86% in MZ, 60% in DZ), suggesting syndrome-specific genes. Apart from partial epilepsies, the MZ casewise concordances were similar to those derived from Australian twin data.The authors were able to apply contemporary classifications to Lennox's twins. The data confirm genetic bases for common generalized epilepsies as well as febrile seizures and provide further support for syndrome-specific genes. Finally, comparable results to our Australian series were obtained, verifying the value of twin studies.en
dc.language.isoenen
dc.subject.otherAdolescenten
dc.subject.otherAdulten
dc.subject.otherAge of Onseten
dc.subject.otherAmericasen
dc.subject.otherAustraliaen
dc.subject.otherChilden
dc.subject.otherChild, Preschoolen
dc.subject.otherDiseases in Twins.classification.diagnosis.genetics.historyen
dc.subject.otherElectroencephalographyen
dc.subject.otherEpilepsy.classification.diagnosis.genetics.historyen
dc.subject.otherFemaleen
dc.subject.otherHistory, 20th Centuryen
dc.subject.otherHumansen
dc.subject.otherInfanten
dc.subject.otherMaleen
dc.subject.otherModels, Statisticalen
dc.subject.otherRegistriesen
dc.subject.otherReproducibility of Resultsen
dc.subject.otherRetrospective Studiesen
dc.subject.otherTerminology as Topicen
dc.subject.otherTwins, Dizygotic.geneticsen
dc.subject.otherTwins, Monozygotic.geneticsen
dc.titleEpilepsy in twins: insights from unique historical data of William Lennox.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationEpilepsy Research Centre, University of Melbourne, Austin Health, Heidelberg West, Victoria, Australiaen
dc.description.pages1127-33en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/15079012en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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