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Title: Ageing has no effect on the volume density of hepatocytes, reticulo-endothelial cells or the extracellular space in livers of female Sprague-Dawley rats.
Austin Authors: Martin, G;Sewell, Richard B;Yeomans, Neville D ;Smallwood, R A
Affiliation: Department of Medicine, Heidelberg Repatriation Hospital, Melbourne, Victoria, Australia
Issue Date: 1-Jul-1992
Publication information: Clinical and Experimental Pharmacology & Physiology; 19(7): 537-9
Abstract: 1. The hepatic reticulo-endothelial cell population is generally assumed to increase in size, along with the liver, during ageing in rats. However, this has not been rigorously established. 2. Using electron microscopy and stereological techniques, the present study has shown that the volume densities of hepatocytes and Kupffer cells (and probably also of endothelial cells, fat storing cells and the extracellular space) of the livers of female Sprague-Dawley rats are the same at 2 and 24-25 months of age. 3. This result indicates that the increase in size of the liver during ageing in the rat is associated with an equivalent increase in the volume of each cell population and the extracellular space.
Gov't Doc #: 1499150
Journal: Clinical and Experimental Pharmacology & Physiology
Type: Journal Article
Subjects: Aging.physiology
Extracellular Space.physiology
Kupffer Cells.cytology
Rats, Inbred Strains
Appears in Collections:Journal articles

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