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Title: HLA-DR2 negative narcolepsy in Australian Caucasians: clinical features, serology and sequence specific oligonucleotide typing.
Austin Authors: Reutens, David C;Haddad, A P;Cantwell, L;Berkovic, Samuel F 
Affiliation: Department of Neurology, Austin Hospital, Melbourne, Australia
Issue Date: 1-Nov-1992
Publication information: Journal of the Neurological Sciences; 113(1): 26-30
Abstract: An almost invariable association with HLA-DR2 and DQw1 has previously been reported in Japanese and caucasian narcoleptics. We performed HLA typing in 18 Australian narcoleptics using serological techniques and sequence specific oligonucleotide probes. HLA-DQw1 was present in 15 patients and DR2 in 12; 3 patients with cataplectic narcolepsy were DR2-negative. The serological haplotype most strongly associated with narcolepsy was DRw15 (a subtype of DR2), DQw1. DRw15-positive patients were positive for the alleles DRB1*1501 and DQB1*0602 defined with oligonucleotide probes. We conclude that the association of narcolepsy with DR2 and DQw1 is not as strong as previously reported and the absence of DR2 or DQw1 does not preclude the diagnosis of classical narcolepsy, at least in caucasians. Secondly, DR2-positive narcoleptics possess characteristic serological subtypes and alleles defined with oligonucleotide probes that are also found in normals. Thirdly, the occurrence of DR2-negative cataplectic narcoleptics points to the existence of more than one narcolepsy susceptibility gene.
Gov't Doc #: 1469452
Journal: Journal of the neurological sciences
Type: Journal Article
Subjects: Adult
Antigen-Antibody Reactions
European Continental Ancestry Group
HLA-DR2 Antigen.analysis.classification.genetics
Oligonucleotide Probes.diagnostic use
Appears in Collections:Journal articles

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