Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9680
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dc.contributor.authorReutens, David Cen
dc.contributor.authorHaddad, A Pen
dc.contributor.authorCantwell, Len
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:51:50Z
dc.date.available2015-05-15T22:51:50Z
dc.date.issued1992-11-01en
dc.identifier.citationJournal of the Neurological Sciences; 113(1): 26-30en
dc.identifier.govdoc1469452en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9680en
dc.description.abstractAn almost invariable association with HLA-DR2 and DQw1 has previously been reported in Japanese and caucasian narcoleptics. We performed HLA typing in 18 Australian narcoleptics using serological techniques and sequence specific oligonucleotide probes. HLA-DQw1 was present in 15 patients and DR2 in 12; 3 patients with cataplectic narcolepsy were DR2-negative. The serological haplotype most strongly associated with narcolepsy was DRw15 (a subtype of DR2), DQw1. DRw15-positive patients were positive for the alleles DRB1*1501 and DQB1*0602 defined with oligonucleotide probes. We conclude that the association of narcolepsy with DR2 and DQw1 is not as strong as previously reported and the absence of DR2 or DQw1 does not preclude the diagnosis of classical narcolepsy, at least in caucasians. Secondly, DR2-positive narcoleptics possess characteristic serological subtypes and alleles defined with oligonucleotide probes that are also found in normals. Thirdly, the occurrence of DR2-negative cataplectic narcoleptics points to the existence of more than one narcolepsy susceptibility gene.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherAntigen-Antibody Reactionsen
dc.subject.otherCataplexy.complicationsen
dc.subject.otherEuropean Continental Ancestry Groupen
dc.subject.otherFemaleen
dc.subject.otherHLA-DR2 Antigen.analysis.classification.geneticsen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherNarcolepsy.ethnology.immunology.physiopathologyen
dc.subject.otherOligonucleotide Probes.diagnostic useen
dc.subject.otherOligonucleotides.classificationen
dc.titleHLA-DR2 negative narcolepsy in Australian Caucasians: clinical features, serology and sequence specific oligonucleotide typing.en
dc.typeJournal Articleen
dc.identifier.journaltitleJournal of the neurological sciencesen
dc.identifier.affiliationDepartment of Neurology, Austin Hospital, Melbourne, Australiaen
dc.description.pages26-30en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1469452en
dc.type.austinJournal Articleen
local.name.researcherBerkovic, Samuel F
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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