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Title: Induction of c-jun expression in vagal motoneurones following axotomy.
Austin Authors: Rutherfurd, S D;Louis, William J ;Gundlach, Andrew L
Affiliation: University of Melbourne, Department of Medicine, Austin, Victoria, Australia
Issue Date: 1-Jun-1992
Publication information: Neuroreport; 3(6): 465-8
Abstract: Using in situ hybridization, we have measured c-jun mRNA expression in the caudal medulla oblongata of the rat following sectioning of the cervical vagus nerve. Twenty four hours after either unilateral cervical vagotomy or nodose ganglionectomy, motoneurones in the ipsilateral dorsal motor nucleus of the vagus and nucleus ambiguus expressed increased (2-3 fold) levels of c-jun mRNA. After 7 days, c-jun mRNA expression was further elevated to levels 8-10-fold higher than basal. These results demonstrate an unusual, long-lasting activation of a member of the 'leucine zipper' class of immediate early gene, and suggest that immediate early genes such as c-jun may be responsible for the regulation of the expression of structural protein and neuropeptide genes that have been demonstrated to occur following nerve injury.
Gov't Doc #: 1391748
Type: Journal Article
Subjects: Animals
Gene Expression Regulation
Genes, jun
Motor Neurons.physiology
Nodose Ganglion.physiology
RNA, Messenger.analysis.biosynthesis
Rats, Wistar
Vagus Nerve.physiology
Appears in Collections:Journal articles

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