Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9595
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dc.contributor.authorRutherfurd, S Den
dc.contributor.authorLouis, William Jen
dc.contributor.authorGundlach, Andrew Len
dc.date.accessioned2015-05-15T22:45:05Z
dc.date.available2015-05-15T22:45:05Z
dc.date.issued1992-06-01en
dc.identifier.citationNeuroreport; 3(6): 465-8en
dc.identifier.govdoc1391748en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9595en
dc.description.abstractUsing in situ hybridization, we have measured c-jun mRNA expression in the caudal medulla oblongata of the rat following sectioning of the cervical vagus nerve. Twenty four hours after either unilateral cervical vagotomy or nodose ganglionectomy, motoneurones in the ipsilateral dorsal motor nucleus of the vagus and nucleus ambiguus expressed increased (2-3 fold) levels of c-jun mRNA. After 7 days, c-jun mRNA expression was further elevated to levels 8-10-fold higher than basal. These results demonstrate an unusual, long-lasting activation of a member of the 'leucine zipper' class of immediate early gene, and suggest that immediate early genes such as c-jun may be responsible for the regulation of the expression of structural protein and neuropeptide genes that have been demonstrated to occur following nerve injury.en
dc.language.isoenen
dc.subject.otherAnimalsen
dc.subject.otherAxons.physiologyen
dc.subject.otherGene Expression Regulationen
dc.subject.otherGenes, junen
dc.subject.otherMaleen
dc.subject.otherMotor Neurons.physiologyen
dc.subject.otherNodose Ganglion.physiologyen
dc.subject.otherRNA, Messenger.analysis.biosynthesisen
dc.subject.otherRatsen
dc.subject.otherRats, Wistaren
dc.subject.otherVagotomyen
dc.subject.otherVagus Nerve.physiologyen
dc.titleInduction of c-jun expression in vagal motoneurones following axotomy.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeuroreporten
dc.identifier.affiliationUniversity of Melbourne, Department of Medicine, Austin, Victoria, Australiaen
dc.description.pages465-8en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/1391748en
dc.type.austinJournal Articleen
local.name.researcherLouis, William J
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en-
crisitem.author.deptClinical Pharmacology and Therapeutics-
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