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Title: Sertraline in paired blood plasma and breast-milk samples from nursing mothers.
Austin Authors: Dodd, Seetal;Stocky, Andrew;Buist, Anne ;Burrows, Graham D;Maguire, Kay;Norman, Trevor R 
Affiliation: Department of Psychiatry, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Jun-2000
Publication information: Human Psychopharmacology; 15(4): 161-264
Abstract: Paired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50-150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1.76+/-1.72 was recorded. The average dose to the infants ranged from 1.1 to 31.1 &mgr;g/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright 2000 John Wiley & Sons, Ltd.
Gov't Doc #: 12404316
DOI: 10.1002/1099-1077(200006)15:4<161::AID-HUP167>3.0.CO;2-2
Journal: Human psychopharmacology
Type: Journal Article
Appears in Collections:Journal articles

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