Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9441
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dc.contributor.authorDodd, Seetalen
dc.contributor.authorStocky, Andrewen
dc.contributor.authorBuist, Anneen
dc.contributor.authorBurrows, Graham Den
dc.contributor.authorMaguire, Kayen
dc.contributor.authorNorman, Trevor Ren
dc.date.accessioned2015-05-15T22:32:20Z
dc.date.available2015-05-15T22:32:20Z
dc.date.issued2000-06-01en
dc.identifier.citationHuman Psychopharmacology; 15(4): 161-264en
dc.identifier.govdoc12404316en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9441en
dc.description.abstractPaired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50-150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1.76+/-1.72 was recorded. The average dose to the infants ranged from 1.1 to 31.1 &mgr;g/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright 2000 John Wiley & Sons, Ltd.en
dc.language.isoenen
dc.titleSertraline in paired blood plasma and breast-milk samples from nursing mothers.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria 3084, Australiaen
dc.identifier.doi10.1002/1099-1077(200006)15:4<161::AID-HUP167>3.0.CO;2-2en
dc.description.pages161-264en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/12404316en
dc.type.austinJournal Articleen
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
crisitem.author.deptPsychiatry (University of Melbourne)-
crisitem.author.deptPsychiatry (University of Melbourne)-
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