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dc.contributor.authorDodd, Seetalen
dc.contributor.authorStocky, Andrewen
dc.contributor.authorBuist, Anneen
dc.contributor.authorBurrows, Graham Den
dc.contributor.authorMaguire, Kayen
dc.contributor.authorNorman, Trevor Ren
dc.identifier.citationHuman Psychopharmacology; 15(4): 161-264en
dc.description.abstractPaired blood and breast-milk samples were collected from 10 nursing mothers receiving sertraline. Samples were collected at steady state when the patients had been taking stable doses of 50-150 mg/day over several weeks. Sertraline concentrations in both fluids were determined using a specific, validated HPLC method. Plasma and milk concentrations showed a wide inter-individual variability for the same dose. Mean plasma concentrations were linearly related to dose, but this was not the case for breast-milk concentrations. An overall milk to plasma ratio of 1.76+/-1.72 was recorded. The average dose to the infants ranged from 1.1 to 31.1 &mgr;g/kg, which is less than 2 per cent of the maternal dose per day. Further studies are necessary to determine if these doses are detrimental to the development of the infant. Copyright 2000 John Wiley & Sons, Ltd.en
dc.titleSertraline in paired blood plasma and breast-milk samples from nursing mothers.en
dc.typeJournal Articleen
dc.identifier.journaltitleHuman psychopharmacologyen
dc.identifier.affiliationDepartment of Psychiatry, University of Melbourne, Austin & Repatriation Medical Centre, Heidelberg, Victoria 3084, Australiaen
dc.type.austinJournal Articleen, Anne
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.grantfulltextnone- (University of Melbourne)- (University of Melbourne)-
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