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Title: Cholecystokinin selectively affects presympathetic vasomotor neurons and sympathetic vasomotor outflow.
Austin Authors: Sartor, Daniela M;Verberne, Anthony J M 
Affiliation: Clinical Pharmacology and Therapeutics Unit, Department of Medicine, Austin and Repatriation Medical Centre, University of Melbourne, Heidelberg, Victoria 3084, Australia
Issue Date: 1-Apr-2002
Publication information: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology; 282(4): R1174-84
Abstract: Cholecystokinin (CCK) is a potential mediator of gastrointestinal vasodilatation during digestion. To determine whether CCK influences sympathetic vasomotor function, we examined the effect of systemic CCK administration on mean arterial blood pressure (MAP), heart rate (HR), lumbar sympathetic nerve discharge (LSND), splanchnic sympathetic nerve discharge (SSND), and the discharge of presympathetic neurons of the rostral ventrolateral medulla (RVLM) in alpha-chloralose-anesthetized rats. CCK (1-8 microg/kg iv) reduced MAP, HR, and SSND and transiently increased LSND. Vagotomy abolished the effects of CCK on MAP and SSND as did the CCK-A receptor antagonist devazepide (0.5 mg/kg iv). The bradycardic effect of CCK was unaltered by vagotomy but abolished by devazepide. CCK increased superior mesenteric arterial conductance but did not alter iliac conductance. CCK inhibited a subpopulation (approximately 49%) of RVLM presympathetic neurons whereas approximately 28% of neurons tested were activated by CCK. The effects of CCK on RVLM neuronal discharge were blocked by devazepide. RVLM neurons inhibited by exogenous CCK acting via CCK-A receptors on vagal afferents may control sympathetic vasomotor outflow to the gastrointestinal tract vasculature.
Gov't Doc #: 11893623
DOI: 10.1152/ajpregu.00500.2001
Journal: American journal of physiology. Regulatory, integrative and comparative physiology
Type: Journal Article
Subjects: Animals
Blood Pressure.drug effects
Bradycardia.chemically induced.physiopathology
Digestive System.blood supply
Heart Rate.drug effects
Hormone Antagonists.pharmacology
Medulla Oblongata.cytology.drug effects.physiology
Motor Neurons.physiology
Peptide Fragments.pharmacology
Rats, Sprague-Dawley
Receptor, Cholecystokinin A
Receptors, Cholecystokinin.antagonists & inhibitors
Splanchnic Nerves.cytology.drug effects.physiology
Sympathetic Nervous System.cytology.drug effects.physiology
Appears in Collections:Journal articles

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