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Title: Seizures in family members of patients with hippocampal sclerosis.
Austin Authors: Briellmann, Regula S;Torn-Broers, Y;Jackson, Graeme D ;Berkovic, Samuel F 
Affiliation: Epilepsy Research Institute, Austin and Repatriation Medical Center, University of Melbourne, Australia
Issue Date: 27-Nov-2001
Publication information: Neurology; 57(10): 1800-4
Abstract: To characterize seizures in family members of patients with refractory temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS).The authors systematically investigated family history (FH) of seizures in 66 probands with histologically proven HS, and in 51 control subjects. A positive FH was defined as at least one first-to-third-degree relative being affected. The odds ratio (OR) to be affected with seizures was calculated for siblings, parents, and aunts/uncles.An FH of seizures was found in 58% of patients, and in 24% of control subjects (p = 0.02). A variety of seizure types were found. Siblings of patients were more likely to be affected than siblings of control subjects (OR 11.5; 95% CI = 1.5 to 86.9 p = 0.003), with febrile convulsions occurring in 5.8% of the siblings of patients. The OR of being affected was 5.7 for parents of patients, and 1.9 for aunts/uncles of patients (p = NS).FH of seizures, particularly febrile convulsions, are a risk factor for TLE with HS. These data suggest that a variety of genes contributing to epilepsy phenotypes in relatives may be involved in the pathogenesis of HS.
Gov't Doc #: 11723267
Journal: Neurology
Type: Journal Article
Subjects: Adult
Diffuse Cerebral Sclerosis of
Epilepsy, Temporal
Genetic Predisposition to Disease.genetics
Odds Ratio
Risk Factors
Seizures, Febrile.diagnosis.genetics.pathology
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