Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9361
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dc.contributor.authorBriellmann, Regula Sen
dc.contributor.authorTorn-Broers, Yen
dc.contributor.authorJackson, Graeme Den
dc.contributor.authorBerkovic, Samuel Fen
dc.date.accessioned2015-05-15T22:25:47Z
dc.date.available2015-05-15T22:25:47Z
dc.date.issued2001-11-27en
dc.identifier.citationNeurology; 57(10): 1800-4en
dc.identifier.govdoc11723267en
dc.identifier.otherPUBMEDen
dc.identifier.urihttp://ahro.austin.org.au/austinjspui/handle/1/9361en
dc.description.abstractTo characterize seizures in family members of patients with refractory temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS).The authors systematically investigated family history (FH) of seizures in 66 probands with histologically proven HS, and in 51 control subjects. A positive FH was defined as at least one first-to-third-degree relative being affected. The odds ratio (OR) to be affected with seizures was calculated for siblings, parents, and aunts/uncles.An FH of seizures was found in 58% of patients, and in 24% of control subjects (p = 0.02). A variety of seizure types were found. Siblings of patients were more likely to be affected than siblings of control subjects (OR 11.5; 95% CI = 1.5 to 86.9 p = 0.003), with febrile convulsions occurring in 5.8% of the siblings of patients. The OR of being affected was 5.7 for parents of patients, and 1.9 for aunts/uncles of patients (p = NS).FH of seizures, particularly febrile convulsions, are a risk factor for TLE with HS. These data suggest that a variety of genes contributing to epilepsy phenotypes in relatives may be involved in the pathogenesis of HS.en
dc.language.isoenen
dc.subject.otherAdulten
dc.subject.otherDiffuse Cerebral Sclerosis of Schilder.diagnosis.genetics.surgeryen
dc.subject.otherEpilepsy, Temporal Lobe.diagnosis.genetics.surgeryen
dc.subject.otherFemaleen
dc.subject.otherGenetic Predisposition to Disease.geneticsen
dc.subject.otherHippocampus.pathology.surgeryen
dc.subject.otherHumansen
dc.subject.otherMaleen
dc.subject.otherOdds Ratioen
dc.subject.otherPhenotypeen
dc.subject.otherPsychosurgeryen
dc.subject.otherRisk Factorsen
dc.subject.otherSeizures, Febrile.diagnosis.genetics.pathologyen
dc.subject.otherTemporal Lobe.pathology.surgeryen
dc.titleSeizures in family members of patients with hippocampal sclerosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleNeurologyen
dc.identifier.affiliationEpilepsy Research Institute, Austin and Repatriation Medical Center, University of Melbourne, Australiaen
dc.description.pages1800-4en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/11723267en
dc.type.austinJournal Articleen
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en-
item.openairetypeJournal Article-
crisitem.author.deptNeurology-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptEpilepsy Research Centre-
crisitem.author.deptNeurology-
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