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Title: | Effects of insulin therapy and glycemic control on distribution of HDL alpha and pre-beta subfractions in non insulin-dependent diabetic subjects. | Austin Authors: | Sasahara, T;Jerums, George ;Nestel, P | Affiliation: | Baker Medical Research Institute, University of Melbourne, Austin, Australia | Issue Date: | 1-Feb-1999 | Publication information: | Nutrition, Metabolism, and Cardiovascular Diseases : Nmcd; 9(1): 19-24 | Abstract: | The heterogeneous population of HDL particles can be separated into six classes which may provide a more sensitive index of cardiovascular risk than HDL cholesterol. The aim of this study was therefore to evaluate HDL distribution in NIDDM.Twenty-five individuals were treated with diet and sulfonylurea and 14 with insulin; both groups had similar plasma lipid profiles and BMI, but the insulin-treated subjects were older and their diabetes was of longer duration. The major findings were a greater proportion of apoA1 in alpha 1-HDL in the insulin-treated group (24.3 +/- 5.2% vs 20.8 +/- 4.0%), which is a desirable profile, and a greater proportion of pre-beta 1-HDL, which are the initial acceptors of cellular cholesterol.Our results suggest a beneficial influence of insulin treatment on reverse cholesterol transport. Moreover, glycemic control (HbA1c) also related to alpha 3-HDL significantly (r = 0.51; p < 0.01), indicating an association between poorer glycemic control and an adverse HDL profile. | Gov't Doc #: | 10726105 | URI: | https://ahro.austin.org.au/austinjspui/handle/1/9214 | Journal: | Nutrition, metabolism, and cardiovascular diseases : NMCD | URL: | https://pubmed.ncbi.nlm.nih.gov/10726105 | Type: | Journal Article | Subjects: | Administration, Oral Aged Analysis of Variance Blood Glucose.metabolism Cholesterol, HDL.drug effects.metabolism Diabetes Mellitus, Type 2.diet therapy.drug therapy Diet Therapy.methods Electrophoresis Female Humans Hypoglycemic Agents.administration & dosage Immunoblotting Insulin.administration & dosage Male Middle Aged Sensitivity and Specificity |
Appears in Collections: | Journal articles |
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