Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/9214
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSasahara, Ten
dc.contributor.authorJerums, Georgeen
dc.contributor.authorNestel, Pen
dc.date.accessioned2015-05-15T22:13:19Z
dc.date.available2015-05-15T22:13:19Z
dc.date.issued1999-02-01en
dc.identifier.citationNutrition, Metabolism, and Cardiovascular Diseases : Nmcd; 9(1): 19-24en
dc.identifier.govdoc10726105en
dc.identifier.otherPUBMEDen
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/9214en
dc.description.abstractThe heterogeneous population of HDL particles can be separated into six classes which may provide a more sensitive index of cardiovascular risk than HDL cholesterol. The aim of this study was therefore to evaluate HDL distribution in NIDDM.Twenty-five individuals were treated with diet and sulfonylurea and 14 with insulin; both groups had similar plasma lipid profiles and BMI, but the insulin-treated subjects were older and their diabetes was of longer duration. The major findings were a greater proportion of apoA1 in alpha 1-HDL in the insulin-treated group (24.3 +/- 5.2% vs 20.8 +/- 4.0%), which is a desirable profile, and a greater proportion of pre-beta 1-HDL, which are the initial acceptors of cellular cholesterol.Our results suggest a beneficial influence of insulin treatment on reverse cholesterol transport. Moreover, glycemic control (HbA1c) also related to alpha 3-HDL significantly (r = 0.51; p < 0.01), indicating an association between poorer glycemic control and an adverse HDL profile.en
dc.language.isoenen
dc.subject.otherAdministration, Oralen
dc.subject.otherAgeden
dc.subject.otherAnalysis of Varianceen
dc.subject.otherBlood Glucose.metabolismen
dc.subject.otherCholesterol, HDL.drug effects.metabolismen
dc.subject.otherDiabetes Mellitus, Type 2.diet therapy.drug therapyen
dc.subject.otherDiet Therapy.methodsen
dc.subject.otherElectrophoresisen
dc.subject.otherFemaleen
dc.subject.otherHumansen
dc.subject.otherHypoglycemic Agents.administration & dosageen
dc.subject.otherImmunoblottingen
dc.subject.otherInsulin.administration & dosageen
dc.subject.otherMaleen
dc.subject.otherMiddle Ageden
dc.subject.otherSensitivity and Specificityen
dc.titleEffects of insulin therapy and glycemic control on distribution of HDL alpha and pre-beta subfractions in non insulin-dependent diabetic subjects.en
dc.typeJournal Articleen
dc.identifier.journaltitleNutrition, metabolism, and cardiovascular diseases : NMCDen
dc.identifier.affiliationBaker Medical Research Institute, University of Melbourne, Austin, Australiaen
dc.description.pages19-24en
dc.relation.urlhttps://pubmed.ncbi.nlm.nih.gov/10726105en
dc.type.austinJournal Articleen
local.name.researcherJerums, George
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptEndocrinology-
Appears in Collections:Journal articles
Show simple item record

Page view(s)

12
checked on Mar 3, 2024

Google ScholarTM

Check


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.