Please use this identifier to cite or link to this item:
Title: Passive ventricular constraint amends the course of heart failure: a study in an ovine model of dilated cardiomyopathy.
Austin Authors: Power, JM;Raman, Jai S ;Dornom, A;Farish, S J;Burrell, Louise M ;Tonkin, Andrew M;Buxton, Brian F ;Alferness, Clif A
Affiliation: Department of Medicine, University of Melbourne, Australia
Issue Date: 1-Dec-1999
Publication information: Cardiovascular Research; 44(3): 549-55
Abstract: Dilated cardiomyopathy (DCM) is associated with a progressive deterioration in cardiac function. We hypothesised that some of the deleterious effects of DCM could be reduced by mechanically limiting the degree of cardiac dilatation.A Transonic 20A cardiac output (CO) flow-probe was implanted in the pulmonary artery of 12 adult (52 +/- 4 kg) sheep. Early heart failure was created by rapid right ventricular (RV) pacing for 21 days at a rate which resulted in an initial 10% decrease in CO (to a maximum of 190 bpm). A custom polyester jacket (Acorn Cardiovascular, St Paul, MN) was then placed, via a partial lower sternotomy, on the ventricular epicardium of all sheep. Animals were randomised either to jacket retention (wrap) or removal (sham). Pacing was recommenced at a higher rate (that initiated a further 10% decrease in CO) for 28 days. Haemodynamic and echocardiographic parameters were determined at baseline, implant and at termination.At termination, the left ventricular fractional shortening was significantly higher (p = 0.03), the degree of mitral valve regurgitation lower (scaled 0-3) (p = 0.03) and the left ventricular long axis area smaller (p = 0.02) in the wrap animals compared with sham.In this model of heart failure, ventricular constraint with a polyester jacket diminished the deterioration in cardiac function associated with progressive dilated cardiomyopathy. These results suggest that maintainance of a more normal cardiac size and shape may be beneficial in patients with dilated cardiomyopathy.
Gov't Doc #: 10690287
Type: Journal Article
Subjects: Animals
Cardiac Pacing, Artificial
Ventricular Remodeling
Appears in Collections:Journal articles

Files in This Item:
File Description SizeFormat 
10690287.pdf511.47 kBAdobe PDFThumbnail
Show full item record

Page view(s)

checked on Nov 30, 2022


checked on Nov 30, 2022

Google ScholarTM


Items in AHRO are protected by copyright, with all rights reserved, unless otherwise indicated.