Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33948
Title: A Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers.
Austin Authors: Rao, Karthik Nagaraja;Arora, Ripudaman;Dange, Prajwal;Nagarkar, Nitin;Mäkitie, Antti A;Kowalski, Luiz P;Eisbruch, Avraham;Hamoir, Marc;Civantos, Francisco J;Vander Poorten, Vincent;Ng, Sweet Ping ;Nuyts, Sandra;Zafereo, Mark;Asarkar, Ameya A;Golusinski, Paweł;Ronen, Ohad;Ferlito, Alfio
Affiliation: Department of Head and Neck Surgical Oncology, All India Institute of Medical Sciences, Raipur, India.
Department of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur, India.
Department of Head and Neck Surgical Oncology, All India Institute of Medical Sciences, Raipur, India.
Department of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur, India.
Department of Otorhinolaryngology, Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Department of Head and Neck Surgery and Otorhinolaringology, A.C. Camargo Cancer Center, São Paulo, Brazil.
Department of Radiation Oncology, University of Michigan Medicine, Ann Arbor, MI, USA.
Department of Head and Neck Surgery, UC Louvain, St Luc University Hospital and King Albert II Cancer Institute, 1200, Brussels, Belgium.
Department of Otolaryngology-Head and Neck Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Otorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.;Department of Oncology, Section Head and Neck Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.
Radiation Oncology
Laboratory of Experimental Radiotherapy, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Leuven, Belgium.;Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Leuven, Belgium.
Department of Head & Neck Surgery, MD Anderson Cancer Center, Houston, TX, 77005, USA.
Department of Otolaryngology Head and Neck Surgery, Louisiana Health Sciences Center, Shreveport, LA, USA.
Department of Otolaryngology and Maxillofacial Surgery, University of Zielona Gora, 65-417, Zielona Gora, Poland.
Department of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel.;Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.
Coordinator of the International Head and Neck Scientific Group, 35100, Padua, Italy.
Issue Date: 7-Oct-2023
Date: 2023
Publication information: Oncology and Therapy 2023-10-07
Abstract: To determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers. PubMed, EMBASE and Cochrane databases from 2000 to 2022 were systematically searched. Clinical studies reporting at least one outcome following curative surgery and adjuvant therapy for comparison of patients with either infranotch T4b (IN-T4b) or T4a tumour. The heterogeneity of the included studies was determined using Tau-squared, Chi-squared, and the Higgins I2 test. The random effects model was used to determine the log odds ratio (logOR). The systematic review comprised 11,790 patients from 16 included studies. Seven studies were included in the meta-analysis (n = 11,381). For IN-T4b patients, the pooled 2 and 5 year overall survival (OS) were 59.3% and 53.2%, 2 and 5 year disease-free survival (DFS) 57.9% and 48.4%, 2 and 5 year disease-specific survival (DSS) 72% and 68%, and 2 and 5 year local control (LC), 47% and 56%, respectively. There was no statistically significant difference in 2 year OS [logOR = 0.28 (-0.47, 1.03), p = 0.46, confidence interval (CI) = 95%], 5 year OS [logOR = 0.7 (-0.4, 1.8), p = 0.54, CI = 95%], 2 year DFS [logOR = 0.22 (-0.35, 0.79), p = 0.45, CI = 95%], 5 year DFS [logOR = 0.17 (-0.42, 0.77), p = 0.57, CI = 95%], 2 year LC [logOR = 0.47 (-0.33, 1.26), p = 0.25, CI = 95%] and 5 year LC [logOR = 0.34 (-0.31, 0.99), p = 0.31, CI = 95%] between IN-T4b and T4a oral cancers. Results of this meta-analysis suggest that IN-T4b oral cancers have similar outcomes to T4a oral cancers, which supports down-staging IN-T4b cancers to T4a cancers.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33948
DOI: 10.1007/s40487-023-00246-3
ORCID: 0000-0002-1420-7366
0000-0003-0522-3118
0000-0002-1952-4061
0000-0002-0732-5487
0000-0002-0451-2404
0000-0002-0481-156X
0000-0002-4102-5197
0000-0001-8547-2768
0000-0003-1341-829X
0000-0002-5540-4796
0000-0001-9028-8746
0000-0002-3937-5315
0000-0001-7084-0695
0000-0002-8247-8002
Journal: Oncology and Therapy
PubMed URL: 37804420
ISSN: 2366-1089
Type: Journal Article
Subjects: Head and neck cancer
Infratemporal fossa
Oral cavity cancer
Outcomes
T4b classification
Appears in Collections:Journal articles

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