Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33948
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dc.contributor.authorRao, Karthik Nagaraja-
dc.contributor.authorArora, Ripudaman-
dc.contributor.authorDange, Prajwal-
dc.contributor.authorNagarkar, Nitin-
dc.contributor.authorMäkitie, Antti A-
dc.contributor.authorKowalski, Luiz P-
dc.contributor.authorEisbruch, Avraham-
dc.contributor.authorHamoir, Marc-
dc.contributor.authorCivantos, Francisco J-
dc.contributor.authorVander Poorten, Vincent-
dc.contributor.authorNg, Sweet Ping-
dc.contributor.authorNuyts, Sandra-
dc.contributor.authorZafereo, Mark-
dc.contributor.authorAsarkar, Ameya A-
dc.contributor.authorGolusinski, Paweł-
dc.contributor.authorRonen, Ohad-
dc.contributor.authorFerlito, Alfio-
dc.date2023-
dc.date.accessioned2023-10-11T06:21:15Z-
dc.date.available2023-10-11T06:21:15Z-
dc.date.issued2023-10-07-
dc.identifier.citationOncology and Therapy 2023-10-07en_US
dc.identifier.issn2366-1089-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33948-
dc.description.abstractTo determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers. PubMed, EMBASE and Cochrane databases from 2000 to 2022 were systematically searched. Clinical studies reporting at least one outcome following curative surgery and adjuvant therapy for comparison of patients with either infranotch T4b (IN-T4b) or T4a tumour. The heterogeneity of the included studies was determined using Tau-squared, Chi-squared, and the Higgins I2 test. The random effects model was used to determine the log odds ratio (logOR). The systematic review comprised 11,790 patients from 16 included studies. Seven studies were included in the meta-analysis (n = 11,381). For IN-T4b patients, the pooled 2 and 5 year overall survival (OS) were 59.3% and 53.2%, 2 and 5 year disease-free survival (DFS) 57.9% and 48.4%, 2 and 5 year disease-specific survival (DSS) 72% and 68%, and 2 and 5 year local control (LC), 47% and 56%, respectively. There was no statistically significant difference in 2 year OS [logOR = 0.28 (-0.47, 1.03), p = 0.46, confidence interval (CI) = 95%], 5 year OS [logOR = 0.7 (-0.4, 1.8), p = 0.54, CI = 95%], 2 year DFS [logOR = 0.22 (-0.35, 0.79), p = 0.45, CI = 95%], 5 year DFS [logOR = 0.17 (-0.42, 0.77), p = 0.57, CI = 95%], 2 year LC [logOR = 0.47 (-0.33, 1.26), p = 0.25, CI = 95%] and 5 year LC [logOR = 0.34 (-0.31, 0.99), p = 0.31, CI = 95%] between IN-T4b and T4a oral cancers. Results of this meta-analysis suggest that IN-T4b oral cancers have similar outcomes to T4a oral cancers, which supports down-staging IN-T4b cancers to T4a cancers.en_US
dc.language.isoeng-
dc.subjectHead and neck canceren_US
dc.subjectInfratemporal fossaen_US
dc.subjectOral cavity canceren_US
dc.subjectOutcomesen_US
dc.subjectT4b classificationen_US
dc.titleA Meta-analysis of Surgical Outcomes of T4a and Infranotch T4b Oral Cancers.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleOncology and Therapyen_US
dc.identifier.affiliationDepartment of Head and Neck Surgical Oncology, All India Institute of Medical Sciences, Raipur, India.en_US
dc.identifier.affiliationDepartment of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur, India.en_US
dc.identifier.affiliationDepartment of Head and Neck Surgical Oncology, All India Institute of Medical Sciences, Raipur, India.en_US
dc.identifier.affiliationDepartment of Otorhinolaryngology and Head Neck Surgery, All India Institute of Medical Sciences, Raipur, India.en_US
dc.identifier.affiliationDepartment of Otorhinolaryngology, Head and Neck Surgery, Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.en_US
dc.identifier.affiliationDepartment of Head and Neck Surgery and Otorhinolaringology, A.C. Camargo Cancer Center, São Paulo, Brazil.en_US
dc.identifier.affiliationDepartment of Radiation Oncology, University of Michigan Medicine, Ann Arbor, MI, USA.en_US
dc.identifier.affiliationDepartment of Head and Neck Surgery, UC Louvain, St Luc University Hospital and King Albert II Cancer Institute, 1200, Brussels, Belgium.en_US
dc.identifier.affiliationDepartment of Otolaryngology-Head and Neck Surgery, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.en_US
dc.identifier.affiliationOtorhinolaryngology-Head and Neck Surgery, University Hospitals Leuven, Leuven Cancer Institute, Leuven, Belgium.;Department of Oncology, Section Head and Neck Oncology, Leuven Cancer Institute, KU Leuven, Leuven, Belgium.en_US
dc.identifier.affiliationRadiation Oncologyen_US
dc.identifier.affiliationLaboratory of Experimental Radiotherapy, Department of Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Leuven, Belgium.;Department of Radiation Oncology, Leuven Cancer Institute, University Hospitals Leuven, 3000, Leuven, Belgium.en_US
dc.identifier.affiliationDepartment of Head & Neck Surgery, MD Anderson Cancer Center, Houston, TX, 77005, USA.en_US
dc.identifier.affiliationDepartment of Otolaryngology Head and Neck Surgery, Louisiana Health Sciences Center, Shreveport, LA, USA.en_US
dc.identifier.affiliationDepartment of Otolaryngology and Maxillofacial Surgery, University of Zielona Gora, 65-417, Zielona Gora, Poland.en_US
dc.identifier.affiliationDepartment of Otolaryngology-Head and Neck Surgery, Galilee Medical Center, Nahariya, Israel.;Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel.en_US
dc.identifier.affiliationCoordinator of the International Head and Neck Scientific Group, 35100, Padua, Italy.en_US
dc.identifier.doi10.1007/s40487-023-00246-3en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-1420-7366en_US
dc.identifier.orcid0000-0003-0522-3118en_US
dc.identifier.orcid0000-0002-1952-4061en_US
dc.identifier.orcid0000-0002-0732-5487en_US
dc.identifier.orcid0000-0002-0451-2404en_US
dc.identifier.orcid0000-0002-0481-156Xen_US
dc.identifier.orcid0000-0002-4102-5197en_US
dc.identifier.orcid0000-0001-8547-2768en_US
dc.identifier.orcid0000-0003-1341-829Xen_US
dc.identifier.orcid0000-0002-5540-4796en_US
dc.identifier.orcid0000-0001-9028-8746en_US
dc.identifier.orcid0000-0002-3937-5315en_US
dc.identifier.orcid0000-0001-7084-0695en_US
dc.identifier.orcid0000-0002-8247-8002en_US
dc.identifier.pubmedid37804420-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.deptRadiation Oncology-
crisitem.author.deptOlivia Newton-John Cancer Wellness and Research Centre-
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