Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33659
Title: Case Commentary: The hidden side of oxacillin resistance in Staphylococcus aureus.
Austin Authors: Giulieri, Stefano G 
Affiliation: Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute for Infection and Immunity , Melbourne, Australia.;Victorian Infectious Disease Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.;Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.
Infectious Diseases
Issue Date: 18-Oct-2023
Date: 2023
Publication information: Antimicrobial Agents and Chemotherapy 2023-10-18; 67(10)
Abstract: Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-lactams in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; however, these tools will miss mec-independent oxacillin resistance. This phenotype is mediated by mutations in cell wall metabolism genes that can be acquired during persistent infections under prolonged antibiotic exposure. The complex case presented by Hess et al. (Antimicrob Agents Chemother 67:e00437-23, 2023, https://doi.org/10.1128/aac.00437-23) highlights the diagnostic and therapeutic challenges in the management of mec-independent oxacillin resistance.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33659
DOI: 10.1128/aac.00716-23
ORCID: 0000-0001-5366-1943
Journal: Antimicrobial Agents and Chemotherapy
Start page: e0071623
PubMed URL: 37655923
ISSN: 1098-6596
Type: Journal Article
Subjects: Staphylococcus aureus
antibiotic resistance
bacterial genomics
within-host evolution
Appears in Collections:Journal articles

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