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https://ahro.austin.org.au/austinjspui/handle/1/33659| Title: | Case Commentary: The hidden side of oxacillin resistance in Staphylococcus aureus. | Austin Authors: | Giulieri, Stefano G | Affiliation: | Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute for Infection and Immunity , Melbourne, Australia.;Victorian Infectious Disease Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.;Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia. Infectious Diseases |
Issue Date: | 18-Oct-2023 | Date: | 2023 | Publication information: | Antimicrobial Agents and Chemotherapy 2023-10-18; 67(10) | Abstract: | Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-lactams in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; however, these tools will miss mec-independent oxacillin resistance. This phenotype is mediated by mutations in cell wall metabolism genes that can be acquired during persistent infections under prolonged antibiotic exposure. The complex case presented by Hess et al. (Antimicrob Agents Chemother 67:e00437-23, 2023, https://doi.org/10.1128/aac.00437-23) highlights the diagnostic and therapeutic challenges in the management of mec-independent oxacillin resistance. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/33659 | DOI: | 10.1128/aac.00716-23 | ORCID: | 0000-0001-5366-1943 | Journal: | Antimicrobial Agents and Chemotherapy | Start page: | e0071623 | PubMed URL: | 37655923 | ISSN: | 1098-6596 | Type: | Journal Article | Subjects: | Staphylococcus aureus antibiotic resistance bacterial genomics within-host evolution |
| Appears in Collections: | Journal articles |
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