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https://ahro.austin.org.au/austinjspui/handle/1/33659Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Giulieri, Stefano G | - |
| dc.date | 2023 | - |
| dc.date.accessioned | 2023-09-06T07:03:28Z | - |
| dc.date.available | 2023-09-06T07:03:28Z | - |
| dc.date.issued | 2023-10-18 | - |
| dc.identifier.citation | Antimicrobial Agents and Chemotherapy 2023-10-18; 67(10) | en_US |
| dc.identifier.issn | 1098-6596 | - |
| dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/33659 | - |
| dc.description.abstract | Acquisition of PBP2a (encoded by the mec gene) is the key resistance mechanism to β-lactams in Staphylococcus aureus. The mec gene can be easily detected by PCR assays; however, these tools will miss mec-independent oxacillin resistance. This phenotype is mediated by mutations in cell wall metabolism genes that can be acquired during persistent infections under prolonged antibiotic exposure. The complex case presented by Hess et al. (Antimicrob Agents Chemother 67:e00437-23, 2023, https://doi.org/10.1128/aac.00437-23) highlights the diagnostic and therapeutic challenges in the management of mec-independent oxacillin resistance. | en_US |
| dc.language.iso | eng | - |
| dc.subject | Staphylococcus aureus | en_US |
| dc.subject | antibiotic resistance | en_US |
| dc.subject | bacterial genomics | en_US |
| dc.subject | within-host evolution | en_US |
| dc.title | Case Commentary: The hidden side of oxacillin resistance in Staphylococcus aureus. | en_US |
| dc.type | Journal Article | en_US |
| dc.identifier.journaltitle | Antimicrobial Agents and Chemotherapy | en_US |
| dc.identifier.affiliation | Department of Microbiology and Immunology, The University of Melbourne at the Doherty Institute for Infection and Immunity , Melbourne, Australia.;Victorian Infectious Disease Service, The Royal Melbourne Hospital at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia.;Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity , Melbourne, Australia. | en_US |
| dc.identifier.affiliation | Infectious Diseases | en_US |
| dc.identifier.doi | 10.1128/aac.00716-23 | en_US |
| dc.type.content | Text | en_US |
| dc.identifier.orcid | 0000-0001-5366-1943 | en_US |
| dc.identifier.pubmedid | 37655923 | - |
| dc.description.startpage | e0071623 | - |
| item.fulltext | No Fulltext | - |
| item.openairetype | Journal Article | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.grantfulltext | none | - |
| item.languageiso639-1 | en | - |
| item.cerifentitytype | Publications | - |
| crisitem.author.dept | Infectious Diseases | - |
| Appears in Collections: | Journal articles | |
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