Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33445
Title: Longer-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant Staphylococcus aureus (CAMERA2) Trial: A Post Hoc Analysis.
Austin Authors: Legg, Amy;Roberts, Matthew A;Davies, Jane;Cass, Alan;Meagher, Niamh;Sud, Archana;Daitch, Vered;Dishon Benattar, Yael;Yahav, Dafna;Paul, Mical;Xinxin, Chen;Ping, Yeo He;Lye, David;Lee, Russel;Robinson, J Owen;Foo, Hong;Tramontana, Adrian R;Bak, Narin;Grenfell, Adelaide;Rogers, Benjamin;Li, Ying;Joshi, Neela;O'Sullivan, Matthew;McKew, Genevieve;Ghosh, Niladri;Schneider, Kellie;Holmes, Natasha E ;Dotel, Ravindra;Chia, Timothy;Archuleta, Sophia;Smith, Simon;Warner, Morgyn S;Titin, Christina;Kalimuddin, Shirin;Roberts, Jason A;Tong, Steven Y C;Davis, Joshua S
Affiliation: Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.;Herston Infectious Diseases Institute, Brisbane, Queensland, Australia.
Eastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.
Department of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.;Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Department of Infectious Diseases, Nepean Hospital and Nepean Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Department of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.;Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.
Infectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.
Infectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.
Infectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.;Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
National Centre for Infectious Diseases, Singapore.
Department of Infectious Diseases, Tan Tock Seng Hospital, Singapore.
National Centre for Infectious Diseases, Singapore.
Infectious Disease Department, Royal Perth Hospital and Fiona Stanley Hospital, PathWest Laboratory Medicine, Perth, Western Australia, Australia.;College of Science, Health, Engineering and Education, Discipline of Health, Murdoch University, Perth, Western Australia, Australia.
Department of Microbiology and Infectious Diseases, NSW Health Pathology, Liverpool, New South Wales, Australia.
Infectious Diseases Department, Western Health, Footscray, Victoria, Australia.;Western Clinical School, University of Melbourne, St Albans, Victoria, Australia.
Infectious Diseases Department, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Monash Health, Department of Medicine, Clayton, Victoria, Australia.
Monash Infectious Diseases, Monash Health, Monash University School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia.
Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.
Department of Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.;New South Wales Health Pathology, Department of Microbiology, Sydney, New South Wales, Australia.;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.
Department of Microbiology and Infectious Diseases, Concord Repatriation and General Hospital, New South Wales Health Pathology, Sydney, NSW, Australia.;Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Department of Infectious Diseases, Wollongong Public Hospital, Wollongong, New South Wales, Australia.
Immunology and Infectious Diseases Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.
Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.
Department of Infectious Diseases, Blacktown Hospital, Sydney, New South Wales, Australia.
Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.
Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.;Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.
Department of Medicine, Cairns Hospital, Cairns, Queensland, Australia.
Microbiology and Infectious Diseases Directorate, South Australia Pathology, Infectious Diseases Unit, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.;Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Department of Infectious Diseases, Singapore General Hospital, Singapore.
Department of Infectious Diseases, Singapore General Hospital, Singapore.;Duke-National University of Singapore Medical School, Programme in Emerging Infectious Diseases, Singapore.
Faculty of Medicine, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.;Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.;Division of Anaesthesiology, Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.
Victorian Infectious Diseases Service, Royal Melbourne Hospital.
Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.;School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.
The Peter Doherty Institute
Infectious Diseases
Issue Date: Jul-2023
Date: 2023
Publication information: Open Forum Infectious Diseases 2023-07; 10(7)
Abstract: The Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial ceased recruitment in July 2018, noting that a higher proportion of patients in the intervention arm (combination therapy) developed acute kidney injury (AKI) compared to the standard therapy (monotherapy) arm. We analyzed the long-term outcomes of participants in CAMERA2 to understand the impact of combination antibiotic therapy and AKI. Trial sites obtained additional follow-up data. The primary outcome was all-cause mortality, censored at death or the date of last known follow-up. Secondary outcomes included kidney failure or a reduction in kidney function (a 40% reduction in estimated glomerular filtration rate to <60 mL/minute/1.73 m2). To determine independent predictors of mortality in this cohort, adjusted hazard ratios were calculated using a Cox proportional hazards regression model. This post hoc analysis included extended follow-up data for 260 patients. Overall, 123 of 260 (47%) of participants died, with a median population survival estimate of 3.4 years (235 deaths per 1000 person-years). Fifty-five patients died within 90 days after CAMERA2 trial randomization; another 68 deaths occurred after day 90. Using univariable Cox proportional hazards regression, mortality was not associated with either the assigned treatment arm in CAMERA2 (hazard ratio [HR], 0.84 [95% confidence interval [CI], .59-1.19]; P = .33) or experiencing an AKI (HR at 1 year, 1.04 [95% CI, .64-1.68]; P = .88). In this cohort of patients hospitalized with methicillin-resistant S aureus bacteremia, we found no association between either treatment arm of the CAMERA2 trial or AKI (using CAMERA2 trial definition) and longer-term mortality.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33445
DOI: 10.1093/ofid/ofad337
ORCID: 0000-0001-8228-1536
0000-0003-3181-9791
0000-0001-6515-2118
0000-0002-8414-6327
0000-0001-9319-5908
0000-0001-6218-435X
0000-0001-9864-5699
Journal: Open Forum Infectious Diseases
Start page: ofad337
PubMed URL: 37496601
Type: Journal Article
Subjects: Staphylococcus aureus bacteremia
acute kidney injury
nephrotoxicity
Appears in Collections:Journal articles

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