Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33445
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dc.contributor.authorLegg, Amy-
dc.contributor.authorRoberts, Matthew A-
dc.contributor.authorDavies, Jane-
dc.contributor.authorCass, Alan-
dc.contributor.authorMeagher, Niamh-
dc.contributor.authorSud, Archana-
dc.contributor.authorDaitch, Vered-
dc.contributor.authorDishon Benattar, Yael-
dc.contributor.authorYahav, Dafna-
dc.contributor.authorPaul, Mical-
dc.contributor.authorXinxin, Chen-
dc.contributor.authorPing, Yeo He-
dc.contributor.authorLye, David-
dc.contributor.authorLee, Russel-
dc.contributor.authorRobinson, J Owen-
dc.contributor.authorFoo, Hong-
dc.contributor.authorTramontana, Adrian R-
dc.contributor.authorBak, Narin-
dc.contributor.authorGrenfell, Adelaide-
dc.contributor.authorRogers, Benjamin-
dc.contributor.authorLi, Ying-
dc.contributor.authorJoshi, Neela-
dc.contributor.authorO'Sullivan, Matthew-
dc.contributor.authorMcKew, Genevieve-
dc.contributor.authorGhosh, Niladri-
dc.contributor.authorSchneider, Kellie-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorDotel, Ravindra-
dc.contributor.authorChia, Timothy-
dc.contributor.authorArchuleta, Sophia-
dc.contributor.authorSmith, Simon-
dc.contributor.authorWarner, Morgyn S-
dc.contributor.authorTitin, Christina-
dc.contributor.authorKalimuddin, Shirin-
dc.contributor.authorRoberts, Jason A-
dc.contributor.authorTong, Steven Y C-
dc.contributor.authorDavis, Joshua S-
dc.date2023-
dc.date.accessioned2023-08-03T00:23:19Z-
dc.date.available2023-08-03T00:23:19Z-
dc.date.issued2023-07-
dc.identifier.citationOpen Forum Infectious Diseases 2023-07; 10(7)en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33445-
dc.description.abstractThe Combination Antibiotic Therapy for Methicillin-Resistant Staphylococcus aureus (CAMERA2) trial ceased recruitment in July 2018, noting that a higher proportion of patients in the intervention arm (combination therapy) developed acute kidney injury (AKI) compared to the standard therapy (monotherapy) arm. We analyzed the long-term outcomes of participants in CAMERA2 to understand the impact of combination antibiotic therapy and AKI. Trial sites obtained additional follow-up data. The primary outcome was all-cause mortality, censored at death or the date of last known follow-up. Secondary outcomes included kidney failure or a reduction in kidney function (a 40% reduction in estimated glomerular filtration rate to <60 mL/minute/1.73 m2). To determine independent predictors of mortality in this cohort, adjusted hazard ratios were calculated using a Cox proportional hazards regression model. This post hoc analysis included extended follow-up data for 260 patients. Overall, 123 of 260 (47%) of participants died, with a median population survival estimate of 3.4 years (235 deaths per 1000 person-years). Fifty-five patients died within 90 days after CAMERA2 trial randomization; another 68 deaths occurred after day 90. Using univariable Cox proportional hazards regression, mortality was not associated with either the assigned treatment arm in CAMERA2 (hazard ratio [HR], 0.84 [95% confidence interval [CI], .59-1.19]; P = .33) or experiencing an AKI (HR at 1 year, 1.04 [95% CI, .64-1.68]; P = .88). In this cohort of patients hospitalized with methicillin-resistant S aureus bacteremia, we found no association between either treatment arm of the CAMERA2 trial or AKI (using CAMERA2 trial definition) and longer-term mortality.en_US
dc.language.isoeng-
dc.subjectStaphylococcus aureus bacteremiaen_US
dc.subjectacute kidney injuryen_US
dc.subjectnephrotoxicityen_US
dc.titleLonger-term Mortality and Kidney Outcomes of Participants in the Combination Antibiotics for Methicillin-Resistant Staphylococcus aureus (CAMERA2) Trial: A Post Hoc Analysis.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleOpen Forum Infectious Diseasesen_US
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.;Herston Infectious Diseases Institute, Brisbane, Queensland, Australia.en_US
dc.identifier.affiliationEastern Health Clinical School, Monash University, Box Hill, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Royal Darwin Hospital, Darwin, Northern Territory, Australia.en_US
dc.identifier.affiliationCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.;Department of Infectious Diseases, Doherty Institute for Infection and Immunity, University of Melbourne and Royal Melbourne Hospital, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Nepean Hospital and Nepean Clinical School, University of Sydney, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Medicine E, Rabin Medical Center, Beilinson Hospital, Petah Tikva, Israel.;Sackler Faculty of Medicine, Tel Aviv University, Ramat-Aviv, Israel.en_US
dc.identifier.affiliationInfectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.en_US
dc.identifier.affiliationInfectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.en_US
dc.identifier.affiliationInfectious Diseases Unit, Sheba Medical Centre, Ramat-Gan, Israel.;Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.en_US
dc.identifier.affiliationYong Loo Lin School of Medicine, National University of Singapore, Singapore.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.en_US
dc.identifier.affiliationNational Centre for Infectious Diseases, Singapore.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Tan Tock Seng Hospital, Singapore.en_US
dc.identifier.affiliationNational Centre for Infectious Diseases, Singapore.en_US
dc.identifier.affiliationInfectious Disease Department, Royal Perth Hospital and Fiona Stanley Hospital, PathWest Laboratory Medicine, Perth, Western Australia, Australia.;College of Science, Health, Engineering and Education, Discipline of Health, Murdoch University, Perth, Western Australia, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Infectious Diseases, NSW Health Pathology, Liverpool, New South Wales, Australia.en_US
dc.identifier.affiliationInfectious Diseases Department, Western Health, Footscray, Victoria, Australia.;Western Clinical School, University of Melbourne, St Albans, Victoria, Australia.en_US
dc.identifier.affiliationInfectious Diseases Department, The Royal Adelaide Hospital, Adelaide, South Australia, Australia.en_US
dc.identifier.affiliationMonash Health, Department of Medicine, Clayton, Victoria, Australia.en_US
dc.identifier.affiliationMonash Infectious Diseases, Monash Health, Monash University School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia.en_US
dc.identifier.affiliationCentre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases and Microbiology, Westmead Hospital, Sydney, New South Wales, Australia.;New South Wales Health Pathology, Department of Microbiology, Sydney, New South Wales, Australia.;Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Infectious Diseases, Concord Repatriation and General Hospital, New South Wales Health Pathology, Sydney, NSW, Australia.;Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Wollongong Public Hospital, Wollongong, New South Wales, Australia.en_US
dc.identifier.affiliationImmunology and Infectious Diseases Unit, John Hunter Hospital, Newcastle, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Department of Medicine, University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Blacktown Hospital, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDivision of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.en_US
dc.identifier.affiliationLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.;Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, Singapore.en_US
dc.identifier.affiliationDepartment of Medicine, Cairns Hospital, Cairns, Queensland, Australia.en_US
dc.identifier.affiliationMicrobiology and Infectious Diseases Directorate, South Australia Pathology, Infectious Diseases Unit, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.;Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Singapore General Hospital, Singapore.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Singapore General Hospital, Singapore.;Duke-National University of Singapore Medical School, Programme in Emerging Infectious Diseases, Singapore.en_US
dc.identifier.affiliationFaculty of Medicine, University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.;Departments of Intensive Care Medicine and Pharmacy, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.;Division of Anaesthesiology, Critical Care Emergency and Pain Medicine, Nîmes University Hospital, University of Montpellier, Nîmes, France.en_US
dc.identifier.affiliationVictorian Infectious Diseases Service, Royal Melbourne Hospital.en_US
dc.identifier.affiliationMenzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.;School of Medicine and Public Health, University of Newcastle, Newcastle, New South Wales, Australia.en_US
dc.identifier.affiliationThe Peter Doherty Instituteen_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.doi10.1093/ofid/ofad337en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0001-8228-1536en_US
dc.identifier.orcid0000-0003-3181-9791en_US
dc.identifier.orcid0000-0001-6515-2118en_US
dc.identifier.orcid0000-0002-8414-6327en_US
dc.identifier.orcid0000-0001-9319-5908en_US
dc.identifier.orcid0000-0001-6218-435Xen_US
dc.identifier.orcid0000-0001-9864-5699en_US
dc.identifier.pubmedid37496601-
dc.description.volume10-
dc.description.issue7-
dc.description.startpageofad337-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
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