Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33385
Title: Plasma neurofilament light in behavioural variant frontotemporal dementia compared to mood and psychotic disorders.
Austin Authors: Eratne, Dhamidhu;Kang, Matthew;Malpas, Charles;Simpson-Yap, Steve;Lewis, Courtney;Dang, Christa;Grewal, Jasleen;Coe, Amy;Dobson, Hannah;Keem, Michael;Chiu, Wei-Hsuan;Kalincik, Tomas;Ooi, Suyi;Darby, David;Brodtmann, Amy ;Hansson, Oskar;Janelidze, Shorena;Blennow, Kaj;Zetterberg, Henrik;Walker, Adam;Dean, Olivia;Berk, Michael;Wannan, Cassandra;Pantelis, Christos;Loi, Samantha M;Walterfang, Mark;Berkovic, Samuel F ;Santillo, Alexander F;Velakoulis, Dennis
Affiliation: Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
The Royal Melbourne Hospital, Melbourne, VIC, Australia.
CORe, The Royal Melbourne Hospital, The University of Melbourne, Melbourne, VIC, Australia.
The University of Melbourne, Melbourne, VIC, Australia.
National Ageing Research Institute, Melbourne, VIC, Australia.
Department of Psychiatry, Alfred Hospital, Melbourne, VIC, Australia.
Department of General Practice, The University of Melbourne, Melbourne, VIC, Australia.
Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Florey Institute of Neuroscience and Mental Health, Parkville, VIC, Australia.
Central Clinical School, Monash University, Melbourne, VIC, Australia.;Neuroscience Department, Alfred Health, Melbourne, VIC, Australia.;Department of Eastern Neurosciences, Box Hill Hospital, Melbourne, VIC, Australia.
Department of Eastern Neurosciences, Box Hill Hospital, Melbourne, VIC, Australia.;Department of Neurology, The Royal Melbourne Hospital, Melbourne, VIC, Australia.;Cognitive Health Initiative, Central Clinical School, Monash University, Melbourne, VIC, Australia.
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Dahlgren's Academy, University of Gothenburg, Gothenburg, Sweden.;Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden.
IMPACT - Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
IMPACT - Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Deakin University, Geelong, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.;Orygen, Melbourne, VIC, Australia.;Centre for Youth Mental Health, The University of Melbourne, Melbourne, VIC, Australia.
Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.;NorthWestern Mental Health, Sunshine Hospital, Melbourne, VIC, Australia.
Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, VIC, Australia.;Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Epilepsy Research Centre
Clinical Memory Research Unit, Department of Clinical Sciences, Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, VIC, Australia.;Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia.
Issue Date: Jan-2024
Date: 2023
Publication information: The Australian and New Zealand journal of Psychiatry 2024-01; 58(1)
Abstract: Blood biomarkers of neuronal injury such as neurofilament light (NfL) show promise to improve diagnosis of neurodegenerative disorders and distinguish neurodegenerative from primary psychiatric disorders (PPD). This study investigated the diagnostic utility of plasma NfL to differentiate behavioural variant frontotemporal dementia (bvFTD, a neurodegenerative disorder commonly misdiagnosed initially as PPD), from PPD, and performance of large normative/reference data sets and models. Plasma NfL was analysed in major depressive disorder (MDD, n = 42), bipolar affective disorder (BPAD, n = 121), treatment-resistant schizophrenia (TRS, n = 82), bvFTD (n = 22), and compared to the reference cohort (Control Group 2, n = 1926, using GAMLSS modelling), and age-matched controls (Control Group 1, n = 96, using general linear models). Large differences were seen between bvFTD (mean NfL 34.9 pg/mL) and all PPDs and controls (all < 11 pg/mL). NfL distinguished bvFTD from PPD with high accuracy, sensitivity (86%), and specificity (88%). GAMLSS models using reference Control Group 2 facilitated precision interpretation of individual levels, while performing equally to or outperforming models using local controls. Slightly higher NfL levels were found in BPAD, compared to controls and TRS. This study adds further evidence on the diagnostic utility of NfL to distinguish bvFTD from PPD of high clinical relevance to a bvFTD differential diagnosis, and includes the largest cohort of BPAD to date. Using large reference cohorts, GAMLSS modelling and the interactive Internet-based application we developed, may have important implications for future research and clinical translation. Studies are underway investigating utility of plasma NfL in diverse neurodegenerative and primary psychiatric conditions in real-world clinical settings.
URI: https://ahro.austin.org.au/austinjspui/handle/1/33385
DOI: 10.1177/00048674231187312
ORCID: 0000-0002-3226-7645
0000-0002-0719-4333
0000-0002-3448-7350
0000-0002-5066-2999
0000-0002-5554-6946
0000-0003-1317-4635
0000-0002-9565-0238
0000-0002-4953-4500
Journal: The Australian and New Zealand Journal of Psychiatry
Start page: 48674231187312
PubMed URL: 37477141
ISSN: 1440-1614
Type: Journal Article
Subjects: Behavioural variant frontotemporal dementia
bipolar
bvFTD
depression
diagnosis
neurofilament
psychiatric disorders
psychiatry
schizophrenia
Appears in Collections:Journal articles

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