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Title: A human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.
Austin Authors: Muhi, Stephen;Osowicki, Joshua;O'Brien, Daniel;Johnson, Paul D R ;Pidot, Sacha;Doerflinger, Marcel;Marshall, Julia L;Pellegrini, Marc;McCarthy, James;Stinear, Timothy P
Affiliation: The Peter Doherty Institute
Tropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.;Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Victoria, Australia.;Department of Paediatrics, University of Melbourne, Victoria, Australia.
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.;Barwon Health, Geelong, Victoria, Australia.
Austin Health
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Issue Date: Jun-2023
Date: 2023
Publication information: PLoS Neglected Tropical Diseases 2023-06; 17(6)
Abstract: Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.
DOI: 10.1371/journal.pntd.0011394
ORCID: 0000-0003-3161-8199
Journal: PLoS Neglected Tropical Diseases
Start page: e0011394
PubMed URL: 37384606
ISSN: 1935-2735
Type: Journal Article
Subjects: Buruli Ulcer/prevention & control
Appears in Collections:Journal articles

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