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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/33241
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dc.contributor.authorMuhi, Stephen-
dc.contributor.authorOsowicki, Joshua-
dc.contributor.authorO'Brien, Daniel-
dc.contributor.authorJohnson, Paul D R-
dc.contributor.authorPidot, Sacha-
dc.contributor.authorDoerflinger, Marcel-
dc.contributor.authorMarshall, Julia L-
dc.contributor.authorPellegrini, Marc-
dc.contributor.authorMcCarthy, James-
dc.contributor.authorStinear, Timothy P-
dc.date2023-
dc.date.accessioned2023-07-14T02:26:48Z-
dc.date.available2023-07-14T02:26:48Z-
dc.date.issued2023-06-
dc.identifier.citationPLoS Neglected Tropical Diseases 2023-06; 17(6)en_US
dc.identifier.issn1935-2735-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/33241-
dc.description.abstractCritical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines for prevention of this neglected tropical disease. Here, we review the current understanding of host-pathogen interactions and correlates of immune protection to explore the case for establishing a controlled human infection model of M. ulcerans infection. We also summarise the overarching safety considerations and present a rationale for selecting a suitable challenge strain.en_US
dc.language.isoeng-
dc.titleA human model of Buruli ulcer: The case for controlled human infection and considerations for selecting a Mycobacterium ulcerans challenge strain.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitlePLoS Neglected Tropical Diseasesen_US
dc.identifier.affiliationThe Peter Doherty Instituteen_US
dc.identifier.affiliationTropical Diseases Research Group, Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, Victoria, Australia.;Infectious Diseases Unit, Department of General Medicine, Royal Children's Hospital Melbourne, Victoria, Australia.;Department of Paediatrics, University of Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationVictorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Victoria, Australia.;Barwon Health, Geelong, Victoria, Australia.en_US
dc.identifier.affiliationAustin Healthen_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.en_US
dc.identifier.doi10.1371/journal.pntd.0011394en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0003-3161-8199en_US
dc.identifier.pubmedid37384606-
dc.description.volume17-
dc.description.issue6-
dc.description.startpagee0011394-
dc.subject.meshtermssecondaryBuruli Ulcer/prevention & control-
local.name.researcherJohnson, Paul D R
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
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