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Title: Clinical Applications of Adsorption: The New Era of Jafron Sorbents.
Austin Authors: Bellomo, Rinaldo ;Ronco, Claudio
Affiliation: Department of Critical Care, School of Medicine, The University of Melbourne, Parkville, Melbourne, Victoria, Australia
International Renal Research Institute, Vicenza, Italy
Australian and New Zealand Intensive Care Research Centre, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia
Data Analytics Research and Evaluation (DARE) Centre
Intensive Care
Department of Intensive Care, Royal Melbourne Hospital, Melbourne, Victoria, Australia
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
Issue Date: 1-Jun-2023
Date: 2023
Publication information: Contributions to Nephrology 2023; 200
Abstract: The Jafron series of sorbent cartridges provides a comprehensive array of coated, highly biocompatible sorbent beads made of styrene-divinylbenzene copolymers. Such beads carry a mean diameter of 0.8 mm with a range from 0.60 to 1.18 mm. The maximal pore size of these coated beads and the volume of the cartridge vary according to the type of cartridge ranging between 50 Da and 60 kDa. The sorbents, the size of the cartridge, the volume of sorbent, and the pore size (which reaches 60 kDa with the HA330 cartridge) aim to take advantage of the principles of molecular adsorption in a variety of diseases from uremic toxin retention to poisoning and drug overdose, from kidney disease to liver failure, from acute respiratory distress syndrome to sepsis, from toxic skin injury to COVID-19. The preliminary data from ex vivo studies, animal investigations, and human pilot work look promising and justify a program of systematic investigation of these products to advance our understanding of how they may be incorporated into our therapeutic arsenal.
DOI: 10.1159/000529845
Journal: Contributions to Nephrology
Start page: 1
End page: 7
PubMed URL: 37263197
ISSN: 1662-2782
Type: Journal Article
Appears in Collections:Journal articles

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