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Title: Validation of the 25 level modified shuttle test in children with cystic fibrosis.
Austin Authors: Corda, Jennifer;E Holland, Anne;Berry, Cassidy Du;Westrupp, Nicole;Cox, Narelle S 
Affiliation: Department of Physiotherapy, Royal Children's Hospital, Melbourne, Australia
Respiratory Research@Alfred, Monash University, Melbourne, Australia.
Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Australia.;Infection and Immunity group, Murdoch Children's Research Institute, Melbourne, Australia.;Department of Paediatrics, University of Melbourne, Melbourne, Australia.
Infection and Immunity group, Murdoch Children's Research Institute, Melbourne, Australia.
Institute for Breathing and Sleep
Department of Physiotherapy, La Trobe University, Melbourne, Australia.
Department of Physiotherapy, Alfred Health, Melbourne, Australia.
Issue Date: Aug-2023
Date: 2023
Publication information: Pediatric Pulmonology 2023; 58(8)
Abstract: To evaluate the validity and reliability of the modified shuttle 25-level test (MST-25) in children with cystic fibrosis (CF). A prospective single center study in clinically stable children with CF. Participants undertook two testing conditions on different days: (1) 2xMST-25 tests; (2) cardiopulmonary exercise test (CPET). Test order was randomized. Nadir oxygen saturation (SpO2 ), peak heart rate (HR), breathlessness (modified Borg), rate of perceived exertion (RPE), energy expenditure (EE) and metabolic equivalents (MET) from the MST-25 and CPET were compared to assess validity, while outcomes from 2xMST-25 tests were compared for reliability. CPET was performed using breath-by-breath analysis and EE from the MST-25 obtained using the SenseWear Armband. Strong correlations were found between MST-25 distance and peak oxygen uptake, peak work and minute ventilation on CPET (all r > 0.7, p < 0.01). Moderate correlations were found between MST-25 distance and CPET for METs (r = 0.5) and HR (r = 0.6). Weak associations between tests were evident for nadir SpO2 (r = 0.1), modified Borg (rs  = 0.2) and RPE (rs  = 0.2). Test-retest reliability was excellent for MST-25 distance (ICC 0.91), peak EE (ICC 0.99) and peak METs (ICC 0.90). Good reliability was achieved for HR (ICC 0.84) and modified Borg score (ICC 0.77), while moderate reliability for nadir SpO2 (ICC 0.64) and RPE (ICC 0.68) was observed. The MST-25 is a valid and reliable field test for the assessment of exercise capacity in children with CF. The MST-25 can be used to accurately monitor exercise capacity and prescribe exercise training, particularly when CPET is not available.
DOI: 10.1002/ppul.26452
Journal: Pediatric Pulmonology
PubMed URL: 37144876
ISSN: 1099-0496
Type: Journal Article
Subjects: cystic fibrosis
exercise testing
exercise tolerance
field tests
Appears in Collections:Journal articles

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