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Title: Prescription Patterns and Testosterone Concentrations Achieved with AndroForte 5% Testosterone Cream in Transgender and Gender Diverse Individuals.
Austin Authors: Nolan, Brendan J ;Zwickl, Sav;Locke, Peter;Simpson, Satu;Li, Ling;Zajac, Jeffrey D ;Cheung, Ada S 
Affiliation: Endocrinology
Medicine (University of Melbourne)
Equinox Gender Diverse Clinic, Thorne Harbour Health, Abbotsford, Victoria, Australia.
Issue Date: 1-Jun-2022
Publication information: The Journal of Sexual Medicine 2022; 19(6)
Abstract: Masculinizing hormone therapy with testosterone is used to align an individual's physical characteristics with their gender identity in trans and gender diverse individuals. Standard testosterone doses and formulations recommended for hypogonadal cisgender men are typically administered. 100 mg AndroForte 5% testosterone cream is the recommended starting dose in hypogonadal cisgender men but there are no data evaluating the use of AndroForte 5% testosterone cream in gender-affirming hormone therapy regimens. To assess the prescription patterns and serum total testosterone concentrations achieved with AndroForte 5% testosterone cream in trans and gender diverse individuals. A retrospective analysis was undertaken of trans and gender diverse individuals at a primary and secondary care clinic in Melbourne, Australia. Seventy-two individuals treated with AndroForte 5% testosterone cream to the torso were included. Testosterone dose and serum total testosterone concentration. Median age was 26 years (IQR 22-30) and median duration of testosterone therapy was 14 months (7-24). Fifty (69%) individuals had a non-binary gender identity. Initial median testosterone dose was 50 mg (50-100) daily. Thirty-eight (53%) commenced doses <100 mg daily, the recommended starting dose for hypogonadal cisgender men. Median total testosterone concentration achieved from 186 individual laboratory results was 11.9 nmol/L (8.1-16.4). Polycythemia was documented in 5 (7%) individuals. AndroForte 5% testosterone cream can be used in individuals with a binary and/or non-binary gender identity seeking masculinization. It can be commenced at a lower dose than that administered to hypogonadal cisgender men for individuals seeking slow masculinization goals. Limitations include the retrospective study design, lack of clinical end points and lack of standardization of timing of laboratory tests in relation to the last dose. This is the first study to evaluate AndroForte 5% testosterone cream in trans and gender diverse individuals and provides insights into prescription patterns in individuals with a non-binary gender identity. AndroForte 5% testosterone cream represents an alternative formulation of testosterone administration for trans and gender diverse individuals seeking masculinization.
DOI: 10.1016/j.jsxm.2022.02.020
Journal: The Journal of Sexual Medicine
Start page: 1049
End page: 1054
PubMed URL: 37057582
ISSN: 1743-6109
Type: Journal Article
Subjects: Gender Identity
Testosterone/therapeutic use
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