Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32690
Title: Immune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbations
Austin Authors: Habel, Jennifer R;Chua, Brendon Y;Kedzierski, Lukasz;Selva, Kevin J;Damelang, Timon;Haycroft, Ebene R;Nguyen, Thi Ho;Koay, Hui-Fern;Nicholson, Suellen;McQuilten, Hayley A;Jia, Xiaoxiao;Allen, Lilith F;Hensen, Luca;Zhang, Wuji;van de Sandt, Carolien E;Neil, Jessica A;Pragastis, Katherine;Lau, Jillian Sy;Jumarang, Jaycee;Allen, E Kaitlynn;Amanant, Fatima;Krammer, Florian;Wragg, Kathleen M;Juno, Jennifer A;Wheatley, Adam K;Tan, Hyon-Xhi;Pell, Gabrielle;Walker, Susan;Audsley, Jennifer;Reynaldi, Arnold;Thevarajan, Irani;Denholm, Justin T;Subbarao, Kanta;Davenport, Miles P;Hogarth, P Mark;Godfrey, Dale I;Cheng, Allen C;Tong, Steven Yc;Bond, Katherine;Williamson, Deborah A;McMahon, James H;Thomas, Paul G;Pannaraj, Pia S;James, Fiona L ;Holmes, Natasha E ;Smibert, Olivia C ;Trubiano, Jason ;Gordon, Claire L ;Chung, Amy W;Whitehead, Clare L;Kent, Stephen J;Lappas, Martha;Rowntree, Louise C;Kedzierska, Katherine
Affiliation: The Peter Doherty Institute
Victorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Department of Infectious Diseases, Alfred Health, Monash University, Melbourne, Victoria, Australia.
Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Department of Microbiology, and.;Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Mercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia.
Department of Infectious Diseases, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Immune Therapies Laboratory, Burnet Institute, Melbourne, Victoria, Australia.;Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.;Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia.
Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.;Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, and Monash Infectious Diseases, Monash Health, Melbourne, Victoria, Australia.
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.
Department of Infectious Diseases, Alfred Health, Monash University, Melbourne, Victoria, Australia.
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Division of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA.;Departments of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, UCLA, Los Angeles, California, USA.
Infectious Diseases
Departments of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, UCLA, Los Angeles, California, USA.;Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Department of Infectious Diseases, and.;National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.
Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.;Pregnancy Research Centre, Royal Women's Hospital, Parkville, Victoria, Australia.
Department of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, Victoria, Australia.;Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, Victoria, Australia.
Obstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.
Issue Date: 10-Apr-2023
metadata.dc.date: 2023
Publication information: JCI insight 2023; 8(7)
Abstract: Pregnancy poses a greater risk for severe COVID-19; however, underlying immunological changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in unvaccinated pregnant and nonpregnant women with acute and convalescent COVID-19, quantifying 217 immunological parameters. Humoral responses to SARS-CoV-2 were similar in pregnant and nonpregnant women, although our systems serology approach revealed distinct antibody and FcγR profiles between pregnant and nonpregnant women. Cellular analyses demonstrated marked differences in NK cell and unconventional T cell activation dynamics in pregnant women. Healthy pregnant women displayed preactivated NK cells and γδ T cells when compared with healthy nonpregnant women, which remained unchanged during acute and convalescent COVID-19. Conversely, nonpregnant women had prototypical activation of NK and γδ T cells. Activation of CD4+ and CD8+ T cells and T follicular helper cells was similar in SARS-CoV-2-infected pregnant and nonpregnant women, while antibody-secreting B cells were increased in pregnant women during acute COVID-19. Elevated levels of IL-8, IL-10, and IL-18 were found in pregnant women in their healthy state, and these cytokine levels remained elevated during acute and convalescent COVID-19. Collectively, we demonstrate perturbations in NK cell and γδ T cell activation in unvaccinated pregnant women with COVID-19, which may impact disease progression and severity during pregnancy.
URI: https://ahro.austin.org.au/austinjspui/handle/1/32690
DOI: 10.1172/jci.insight.167157
ORCID: 
Journal: JCI Insight
Type: Journal Article
Subjects: Immunology
Infectious disease
Innate immunity
NK cells
T cells
Appears in Collections:Journal articles

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