Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32690
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dc.contributor.authorHabel, Jennifer R-
dc.contributor.authorChua, Brendon Y-
dc.contributor.authorKedzierski, Lukasz-
dc.contributor.authorSelva, Kevin J-
dc.contributor.authorDamelang, Timon-
dc.contributor.authorHaycroft, Ebene R-
dc.contributor.authorNguyen, Thi Ho-
dc.contributor.authorKoay, Hui-Fern-
dc.contributor.authorNicholson, Suellen-
dc.contributor.authorMcQuilten, Hayley A-
dc.contributor.authorJia, Xiaoxiao-
dc.contributor.authorAllen, Lilith F-
dc.contributor.authorHensen, Luca-
dc.contributor.authorZhang, Wuji-
dc.contributor.authorvan de Sandt, Carolien E-
dc.contributor.authorNeil, Jessica A-
dc.contributor.authorPragastis, Katherine-
dc.contributor.authorLau, Jillian Sy-
dc.contributor.authorJumarang, Jaycee-
dc.contributor.authorAllen, E Kaitlynn-
dc.contributor.authorAmanant, Fatima-
dc.contributor.authorKrammer, Florian-
dc.contributor.authorWragg, Kathleen M-
dc.contributor.authorJuno, Jennifer A-
dc.contributor.authorWheatley, Adam K-
dc.contributor.authorTan, Hyon-Xhi-
dc.contributor.authorPell, Gabrielle-
dc.contributor.authorWalker, Susan-
dc.contributor.authorAudsley, Jennifer-
dc.contributor.authorReynaldi, Arnold-
dc.contributor.authorThevarajan, Irani-
dc.contributor.authorDenholm, Justin T-
dc.contributor.authorSubbarao, Kanta-
dc.contributor.authorDavenport, Miles P-
dc.contributor.authorHogarth, P Mark-
dc.contributor.authorGodfrey, Dale I-
dc.contributor.authorCheng, Allen C-
dc.contributor.authorTong, Steven Yc-
dc.contributor.authorBond, Katherine-
dc.contributor.authorWilliamson, Deborah A-
dc.contributor.authorMcMahon, James H-
dc.contributor.authorThomas, Paul G-
dc.contributor.authorPannaraj, Pia S-
dc.contributor.authorJames, Fiona L-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorSmibert, Olivia C-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorGordon, Claire L-
dc.contributor.authorChung, Amy W-
dc.contributor.authorWhitehead, Clare L-
dc.contributor.authorKent, Stephen J-
dc.contributor.authorLappas, Martha-
dc.contributor.authorRowntree, Louise C-
dc.contributor.authorKedzierska, Katherine-
dc.date2023-
dc.date.accessioned2023-04-17T06:28:03Z-
dc.date.available2023-04-17T06:28:03Z-
dc.date.issued2023-04-10-
dc.identifier.citationJCI insight 2023; 8(7)en_US
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32690-
dc.description.abstractPregnancy poses a greater risk for severe COVID-19; however, underlying immunological changes associated with SARS-CoV-2 during pregnancy are poorly understood. We defined immune responses to SARS-CoV-2 in unvaccinated pregnant and nonpregnant women with acute and convalescent COVID-19, quantifying 217 immunological parameters. Humoral responses to SARS-CoV-2 were similar in pregnant and nonpregnant women, although our systems serology approach revealed distinct antibody and FcγR profiles between pregnant and nonpregnant women. Cellular analyses demonstrated marked differences in NK cell and unconventional T cell activation dynamics in pregnant women. Healthy pregnant women displayed preactivated NK cells and γδ T cells when compared with healthy nonpregnant women, which remained unchanged during acute and convalescent COVID-19. Conversely, nonpregnant women had prototypical activation of NK and γδ T cells. Activation of CD4+ and CD8+ T cells and T follicular helper cells was similar in SARS-CoV-2-infected pregnant and nonpregnant women, while antibody-secreting B cells were increased in pregnant women during acute COVID-19. Elevated levels of IL-8, IL-10, and IL-18 were found in pregnant women in their healthy state, and these cytokine levels remained elevated during acute and convalescent COVID-19. Collectively, we demonstrate perturbations in NK cell and γδ T cell activation in unvaccinated pregnant women with COVID-19, which may impact disease progression and severity during pregnancy.en_US
dc.subjectImmunologyen_US
dc.subjectInfectious diseaseen_US
dc.subjectInnate immunityen_US
dc.subjectNK cellsen_US
dc.subjectT cellsen_US
dc.titleImmune profiling of SARS-CoV-2 infection during pregnancy reveals NK cell and γδ T cell perturbationsen_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleJCI Insighten_US
dc.identifier.affiliationThe Peter Doherty Instituteen_US
dc.identifier.affiliationVictorian Infectious Diseases Reference Laboratory, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Alfred Health, Monash University, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDivision of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA.en_US
dc.identifier.affiliationDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.en_US
dc.identifier.affiliationDepartment of Microbiology, and.;Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.en_US
dc.identifier.affiliationMercy Perinatal Research Centre, Mercy Hospital for Women, Heidelberg, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;WHO Collaborating Centre for Reference and Research on Influenza, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.en_US
dc.identifier.affiliationImmune Therapies Laboratory, Burnet Institute, Melbourne, Victoria, Australia.;Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Victoria, Australia.;Department of Clinical Pathology, University of Melbourne, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationSchool of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.;Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, and Monash Infectious Diseases, Monash Health, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationVictorian Infectious Diseases Service, Royal Melbourne Hospital, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;Department of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia.en_US
dc.identifier.affiliationDepartment of Infectious Diseases, Alfred Health, Monash University, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.en_US
dc.identifier.affiliationDivision of Infectious Diseases, Children's Hospital Los Angeles, Los Angeles, California, USA.;Departments of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, UCLA, Los Angeles, California, USA.en_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationDepartments of Pediatrics, Molecular Microbiology and Immunology, Keck School of Medicine, UCLA, Los Angeles, California, USA.;Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Centre for Antibiotic Allergy and Research, Department of Infectious Diseases, Austin Health, Heidelberg, Victoria, Australia.;Department of Infectious Diseases, and.;National Centre for Infections in Cancer, Peter McCallum Cancer Centre, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Obstetrics and Gynaecology, University of Melbourne, Parkville, Victoria, Australia.;Pregnancy Research Centre, Royal Women's Hospital, Parkville, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.;ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Melbourne, Victoria, Australia.;Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationObstetrics, Nutrition and Endocrinology Group, Department of Obstetrics and Gynaecology, University of Melbourne, Victoria, Australia.en_US
dc.identifier.doi10.1172/jci.insight.167157en_US
dc.type.contentTexten_US
local.name.researcherGordon, Claire L
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.fulltextNo Fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
crisitem.author.deptInfectious Diseases-
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