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Title: Clinical Oncology Society of Australia Position Statement: 2022 update to the safe handling of monoclonal antibodies in healthcare settings.
Austin Authors: Ryan, Marissa;Lam, Neil;Wright, Kate;Siderov, Jim 
Affiliation: Department of Pharmacy, Princess Alexandra Hospital, Brisbane, Australia.
Icon Cancer Centre River City Pharmacy, Brisbane, Australia.
Central West Cancer Care Centre, Orange, Australia.
Issue Date: Dec-2023
Date: 2023
Publication information: Asia-Pacific Journal of Clinical Oncology 2023-12; 19(6)
Abstract: The aims were to (a) review the scientific literature on occupational risk, including exposure mechanisms and risk assessment, with regards to handling monoclonal antibodies (mABs) in healthcare settings; and (b) update the recommendations in the Clinical Oncology Society of Australia (COSA) safe handling of monoclonal antibodies in healthcare settings position statement, published in 2013. A literature search was conducted between April 24, 2022, and July 3, 2022, to identify evidence relating to occupational exposure and handling of mABs in healthcare settings. Evidence in the literature was compared to the Position Statement published in 2013, and any potential additions, deletions, or revisions were discussed by the authors, and then agreed changes were made. Thirty-nine references were included in this update, comprising of the 2013 Position Statement itself and 10 of its references, as well as 28 new references. The risks to healthcare workers in the preparation and administration of mABs arise from four distinct exposure mechanisms: dermal, mucosal, inhalation, and oral. Updates included recommendations on using protective eyewear during the preparation and administration of mABs, developing a local institutional risk assessment tool and handling recommendations, considerations for using closed system transfer devices, and to have awareness of the nomenclature change from 2021 for new mABs. Practitioners should follow the 14 recommendations to lower occupational risk when handling mABs. Another Position Statement update should occur in 5-10 years to ensure the currency of recommendations.
DOI: 10.1111/ajco.13943
ORCID: 0000-0001-9223-0740
Journal: Asia-Pacific Journal of Clinical Oncology
PubMed URL: 36899469
ISSN: 1743-7563
Type: Journal Article
Subjects: cancer services
monoclonal antibodies
safe handling
Appears in Collections:Journal articles

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