Austin Health

Title
Dose intensification strategy influences infliximab pharmacokinetics but not clinical response after the same number of doses.
Publication Date
2023-05
Author(s)
Srinivasan, Ashish
De Cruz, Peter P
Sam, Melissa
Toong, Catherine
van Langenberg, Daniel R
Subject
Anti-tumor necrosis factor
Crohn's disease
Dose intensification
Secondary loss of response
Tertiary nonresponse
Tertiary response
Therapeutic drug monitoring
Ulcerative colitis
Type of document
Journal Article
OrcId
0000-0001-5952-1570
0000-0002-3399-7236
#PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
0000-0003-3662-6307
DOI
10.1111/jgh.16133
Abstract
The optimal infliximab dose intensification strategy to address secondary loss of response (LOR) remains unclear. This study aimed to compare clinical and pharmacokinetic outcomes following (i) upfront infliximab re-induction with (ii) ongoing 6-weekly dose interval shortening (DIS), after the same number of doses.
Link
Citation
Journal of Gastroenterology and Hepatology 2023-05; 38(5)
Jornal Title
Journal of Gastroenterology and Hepatology
ISSN
1440-1746

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