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https://ahro.austin.org.au/austinjspui/handle/1/32095| Title: | Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals. | Austin Authors: | von Borstel, Anouk;Nguyen, Thi Ho;Rowntree, Louise C;Ashhurst, Thomas M;Allen, Lilith F;Howson, Lauren J;Holmes, Natasha E ;Smibert, Olivia C ;Trubiano, Jason ;Gordon, Claire L ;Cheng, Allen C;Kent, Stephen J;Rossjohn, Jamie;Kedzierska, Katherine;Davey, Martin S | Affiliation: | Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, 2050, Australia. Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. Infectious Diseases Centre for Antibiotic Allergy and Research Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, 3004, Australia. Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. |
Issue Date: | 25-Jan-2023 | Date: | 2023 | Publication information: | Immunology and Cell Biology 2023; 101(4) | Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defence against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3 CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32095 | DOI: | 10.1111/imcb.12623 | ORCID: | 0000-0002-3605-7936 0000-0001-7269-7773 0000-0002-8539-4891 0000-0001-6141-335X 0000-0002-3463-3127 |
Journal: | Immunology and Cell Biology | PubMed URL: | 36698330 | ISSN: | 1440-1711 | Type: | Journal Article | Subjects: | COVID-19 SARS-CoV-2 Vδ1 T cells Vδ2 T cells γδ T cells |
| Appears in Collections: | Journal articles |
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