Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.

2023-01-25

von Borstel, Anouk

Nguyen, Thi Ho

Rowntree, Louise C

Ashhurst, Thomas M

Allen, Lilith F

Howson, Lauren J

Holmes, Natasha E

Smibert, Olivia C

Trubiano, Jason

Gordon, Claire L

Cheng, Allen C

Kent, Stephen J

Rossjohn, Jamie

Kedzierska, Katherine

Davey, Martin S

COVID-19

SARS-CoV-2

Vδ1 T cells

Vδ2 T cells

γδ T cells

Journal Article

0000-0002-3605-7936

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0000-0001-7269-7773

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0000-0002-8539-4891

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0000-0001-6141-335X

0000-0002-3463-3127

10.1111/imcb.12623

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defence against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3 CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals.

link

Immunology and Cell Biology 2023; 101(4)

Immunology and Cell Biology

1440-1711