Please use this identifier to cite or link to this item:
https://ahro.austin.org.au/austinjspui/handle/1/32095
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | von Borstel, Anouk | - |
dc.contributor.author | Nguyen, Thi Ho | - |
dc.contributor.author | Rowntree, Louise C | - |
dc.contributor.author | Ashhurst, Thomas M | - |
dc.contributor.author | Allen, Lilith F | - |
dc.contributor.author | Howson, Lauren J | - |
dc.contributor.author | Holmes, Natasha E | - |
dc.contributor.author | Smibert, Olivia C | - |
dc.contributor.author | Trubiano, Jason | - |
dc.contributor.author | Gordon, Claire L | - |
dc.contributor.author | Cheng, Allen C | - |
dc.contributor.author | Kent, Stephen J | - |
dc.contributor.author | Rossjohn, Jamie | - |
dc.contributor.author | Kedzierska, Katherine | - |
dc.contributor.author | Davey, Martin S | - |
dc.date | 2023 | - |
dc.date.accessioned | 2023-02-07T05:52:04Z | - |
dc.date.available | 2023-02-07T05:52:04Z | - |
dc.date.issued | 2023-01-25 | - |
dc.identifier.citation | Immunology and Cell Biology 2023; 101(4) | en_US |
dc.identifier.issn | 1440-1711 | - |
dc.identifier.uri | https://ahro.austin.org.au/austinjspui/handle/1/32095 | - |
dc.description.abstract | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defence against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3 CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals. | en_US |
dc.language.iso | eng | - |
dc.subject | COVID-19 | en_US |
dc.subject | SARS-CoV-2 | en_US |
dc.subject | Vδ1 T cells | en_US |
dc.subject | Vδ2 T cells | en_US |
dc.subject | γδ T cells | en_US |
dc.title | Circulating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals. | en_US |
dc.type | Journal Article | en_US |
dc.identifier.journaltitle | Immunology and Cell Biology | en_US |
dc.identifier.affiliation | Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. | en_US |
dc.identifier.affiliation | Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. | en_US |
dc.identifier.affiliation | Sydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, 2050, Australia. | en_US |
dc.identifier.affiliation | Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. | en_US |
dc.identifier.affiliation | Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. | en_US |
dc.identifier.affiliation | Infectious Diseases | en_US |
dc.identifier.affiliation | Centre for Antibiotic Allergy and Research | en_US |
dc.identifier.affiliation | Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. | en_US |
dc.identifier.affiliation | Infection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, 3004, Australia. | en_US |
dc.identifier.affiliation | Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia. | en_US |
dc.identifier.affiliation | Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia. | en_US |
dc.identifier.doi | 10.1111/imcb.12623 | en_US |
dc.type.content | Text | en_US |
dc.identifier.orcid | 0000-0002-3605-7936 | en_US |
dc.identifier.orcid | 0000-0001-7269-7773 | en_US |
dc.identifier.orcid | 0000-0002-8539-4891 | en_US |
dc.identifier.orcid | 0000-0001-6141-335X | en_US |
dc.identifier.orcid | 0000-0002-3463-3127 | en_US |
dc.identifier.pubmedid | 36698330 | - |
local.name.researcher | Gordon, Claire L | - |
item.fulltext | No Fulltext | - |
item.openairetype | Journal Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Infectious Diseases | - |
crisitem.author.dept | Data Analytics Research and Evaluation (DARE) Centre | - |
crisitem.author.dept | Infectious Diseases | - |
crisitem.author.dept | Infectious Diseases | - |
crisitem.author.dept | Medicine (University of Melbourne) | - |
crisitem.author.dept | Centre for Antibiotic Allergy and Research | - |
crisitem.author.dept | Infectious Diseases | - |
Appears in Collections: | Journal articles |
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