Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32095
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dc.contributor.authorvon Borstel, Anouk-
dc.contributor.authorNguyen, Thi Ho-
dc.contributor.authorRowntree, Louise C-
dc.contributor.authorAshhurst, Thomas M-
dc.contributor.authorAllen, Lilith F-
dc.contributor.authorHowson, Lauren J-
dc.contributor.authorHolmes, Natasha E-
dc.contributor.authorSmibert, Olivia C-
dc.contributor.authorTrubiano, Jason-
dc.contributor.authorGordon, Claire L-
dc.contributor.authorCheng, Allen C-
dc.contributor.authorKent, Stephen J-
dc.contributor.authorRossjohn, Jamie-
dc.contributor.authorKedzierska, Katherine-
dc.contributor.authorDavey, Martin S-
dc.date2023-
dc.date.accessioned2023-02-07T05:52:04Z-
dc.date.available2023-02-07T05:52:04Z-
dc.date.issued2023-01-25-
dc.identifier.citationImmunology and Cell Biology 2023; 101(4)en_US
dc.identifier.issn1440-1711-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32095-
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes severe coronavirus disease 2019 (COVID-19) in a small proportion of infected individuals. The immune system plays an important role in the defence against SARS-CoV-2, but our understanding of the cellular immune parameters that contribute to severe COVID-19 disease is incomplete. Here, we show that populations of effector γδ T cells are associated with COVID-19 in unvaccinated patients with acute disease. We found that circulating CD27neg CD45RA+ CX3 CR1+ Vδ1effector cells expressing Granzymes (Gzms) were enriched in COVID-19 patients with acute disease. Moreover, higher frequencies of GzmB+ Vδ2+ T cells were observed in acute COVID-19 patients. SARS-CoV-2 infection did not alter the γδ T cell receptor repertoire of either Vδ1+ or Vδ2+ subsets. Our work demonstrates an association between effector populations of γδ T cells and acute COVID-19 in unvaccinated individuals.en_US
dc.language.isoeng-
dc.subjectCOVID-19en_US
dc.subjectSARS-CoV-2en_US
dc.subjectVδ1 T cellsen_US
dc.subjectVδ2 T cellsen_US
dc.subjectγδ T cellsen_US
dc.titleCirculating effector γδ T cell populations are associated with acute coronavirus disease 19 in unvaccinated individuals.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleImmunology and Cell Biologyen_US
dc.identifier.affiliationInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.en_US
dc.identifier.affiliationSydney Cytometry Core Research Facility, Charles Perkins Centre, Centenary Institute and University of Sydney, Sydney, NSW, 2050, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.en_US
dc.identifier.affiliationInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.en_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationCentre for Antibiotic Allergy and Researchen_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.en_US
dc.identifier.affiliationInfection Prevention and Healthcare Epidemiology Unit, Alfred Health, Melbourne, VIC, 3004, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, 3000, Australia.en_US
dc.identifier.affiliationInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, 3800, Australia.en_US
dc.identifier.doi10.1111/imcb.12623en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-3605-7936en_US
dc.identifier.orcid0000-0001-7269-7773en_US
dc.identifier.orcid0000-0002-8539-4891en_US
dc.identifier.orcid0000-0001-6141-335Xen_US
dc.identifier.orcid0000-0002-3463-3127en_US
dc.identifier.pubmedid36698330-
local.name.researcherGordon, Claire L-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptData Analytics Research and Evaluation (DARE) Centre-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptMedicine (University of Melbourne)-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
crisitem.author.deptInfectious Diseases-
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