Mechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease.

2023-02

Stock, Angus T

Parsons, Sarah

D'Silva, Damian B

Hansen, Jacinta A

Sharma, Varun J

James, Fiona L

Starkey, Graham M

D'Costa, Rohit

Gordon, Claire L

Wicks, Ian P

coronary artery remodeling

Kawasaki disease

Journal Article

0000-0002-3386-1857

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10.1002/art.42340

Remodeling of the coronary arteries is a common feature in severe cases of Kawasaki disease (KD). This pathology is driven by the dysregulated proliferation of vascular fibroblasts, which can lead to coronary artery aneurysms, stenosis, and myocardial ischemia. We undertook this study to investigate whether inhibiting fibroblast proliferation might be an effective therapeutic strategy to prevent coronary artery remodeling in KD.

link

Arthritis & rheumatology 2023; 75(2):305-317

Arthritis & rheumatology

2326-5205