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https://ahro.austin.org.au/austinjspui/handle/1/32081| Title: | Mechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease. | Austin Authors: | Stock, Angus T;Parsons, Sarah;D'Silva, Damian B;Hansen, Jacinta A;Sharma, Varun J;James, Fiona L ;Starkey, Graham M ;D'Costa, Rohit;Gordon, Claire L ;Wicks, Ian P | Affiliation: | Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. Department of Forensic Medicine, Monash University, and Victorian Institute of Forensic Medicine, Melbourne, Victoria, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. Liver & Intestinal Transplant Unit, Department of Surgery, and Department of Cardiac Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia. Infectious Diseases Liver & Intestinal Transplant Unit and Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia. DonateLife Victoria, Carlton, Victoria, Australia, and Department of Intensive Care Medicine, Melbourne Health, Melbourne, Victoria, Australia. Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, and North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia. Walter and Eliza Hall Institute of Medical Research, Rheumatology Unit, The Royal Melbourne Hospital, and University of Melbourne, Department of Medical Biology, Victoria, Australia. Victorian Liver Transplant Unit Cardiac Surgery |
Issue Date: | Feb-2023 | Date: | 2022 | Publication information: | Arthritis & rheumatology 2023; 75(2):305-317 | Abstract: | Remodeling of the coronary arteries is a common feature in severe cases of Kawasaki disease (KD). This pathology is driven by the dysregulated proliferation of vascular fibroblasts, which can lead to coronary artery aneurysms, stenosis, and myocardial ischemia. We undertook this study to investigate whether inhibiting fibroblast proliferation might be an effective therapeutic strategy to prevent coronary artery remodeling in KD. | URI: | https://ahro.austin.org.au/austinjspui/handle/1/32081 | DOI: | 10.1002/art.42340 | ORCID: | 0000-0002-3386-1857 |
Journal: | Arthritis & rheumatology | Start page: | 305 | End page: | 317 | PubMed URL: | 36057112 | ISSN: | 2326-5205 | Type: | Journal Article | Subjects: | coronary artery remodeling Kawasaki disease Mucocutaneous Lymph Node Syndrome/drug therapy Coronary Vessels/pathology Sirolimus/pharmacology |
| Appears in Collections: | Journal articles |
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