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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32081
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dc.contributor.authorStock, Angus T-
dc.contributor.authorParsons, Sarah-
dc.contributor.authorD'Silva, Damian B-
dc.contributor.authorHansen, Jacinta A-
dc.contributor.authorSharma, Varun J-
dc.contributor.authorJames, Fiona L-
dc.contributor.authorStarkey, Graham M-
dc.contributor.authorD'Costa, Rohit-
dc.contributor.authorGordon, Claire L-
dc.contributor.authorWicks, Ian P-
dc.date2022-
dc.date.accessioned2023-02-07T05:37:57Z-
dc.date.available2023-02-07T05:37:57Z-
dc.date.issued2023-02-
dc.identifier.citationArthritis & rheumatology 2023; 75(2):305-317en_US
dc.identifier.issn2326-5205-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32081-
dc.description.abstractRemodeling of the coronary arteries is a common feature in severe cases of Kawasaki disease (KD). This pathology is driven by the dysregulated proliferation of vascular fibroblasts, which can lead to coronary artery aneurysms, stenosis, and myocardial ischemia. We undertook this study to investigate whether inhibiting fibroblast proliferation might be an effective therapeutic strategy to prevent coronary artery remodeling in KD.en_US
dc.language.isoeng-
dc.subjectcoronary artery remodelingen_US
dc.subjectKawasaki diseaseen_US
dc.titleMechanistic Target of Rapamycin Inhibition Prevents Coronary Artery Remodeling in a Murine Model of Kawasaki Disease.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleArthritis & rheumatologyen_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Forensic Medicine, Monash University, and Victorian Institute of Forensic Medicine, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationLiver & Intestinal Transplant Unit, Department of Surgery, and Department of Cardiac Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationInfectious Diseasesen_US
dc.identifier.affiliationLiver & Intestinal Transplant Unit and Department of Surgery, The University of Melbourne, Austin Health, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDonateLife Victoria, Carlton, Victoria, Australia, and Department of Intensive Care Medicine, Melbourne Health, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, and North Eastern Public Health Unit, Austin Health, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationWalter and Eliza Hall Institute of Medical Research, Rheumatology Unit, The Royal Melbourne Hospital, and University of Melbourne, Department of Medical Biology, Victoria, Australia.en_US
dc.identifier.affiliationVictorian Liver Transplant Uniten_US
dc.identifier.affiliationCardiac Surgeryen_US
dc.identifier.doi10.1002/art.42340en_US
dc.type.contentTexten_US
dc.identifier.orcid0000-0002-3386-1857en_US
dc.identifier.pubmedid36057112-
dc.description.volume75-
dc.description.issue2-
dc.description.startpage305-
dc.description.endpage317-
dc.subject.meshtermssecondaryMucocutaneous Lymph Node Syndrome/drug therapy-
dc.subject.meshtermssecondaryCoronary Vessels/pathology-
dc.subject.meshtermssecondarySirolimus/pharmacology-
local.name.researcherGordon, Claire L
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextnone-
item.languageiso639-1en-
item.cerifentitytypePublications-
crisitem.author.deptInfectious Diseases-
crisitem.author.deptCentre for Antibiotic Allergy and Research-
crisitem.author.deptVictorian Liver Transplant Unit-
crisitem.author.deptInfectious Diseases-
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