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Title: Rates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL 18F-MK6240 PET study.
Austin Authors: Krishnadas, Natasha ;Doré, Vincent ;Robertson, Joanne S;Ward, Larry;Fowler, Christopher;Masters, Colin L ;Bourgeat, Pierrick;Fripp, Jurgen;Villemagne, Victor L ;Rowe, Christopher C 
Affiliation: Molecular Imaging and Therapy
The Florey Institute of Neuroscience and Mental Health
Health and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia.
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Issue Date: 27-Jan-2023
Date: 2023
Publication information: EBioMedicine 2023; 88
Abstract: Tau positron emission tomography (PET) imaging enables longitudinal observation of tau accumulation in Alzheimer's disease (AD). 18F-MK6240 is a high affinity tracer for the paired helical filaments of tau in AD, widely used in clinical trials, despite sparse longitudinal natural history data. We aimed to evaluate the natural history of tau accumulation, and the impact of disease stage and reference region on the magnitude and effect size of regional change.
DOI: 10.1016/j.ebiom.2023.104450
Journal: EBioMedicine
Start page: 104450
PubMed URL: 36709581
ISSN: 2352-3964
Type: Journal Article
Subjects: (18)F-MK6240
Alzheimer's disease
Positron emission tomography (PET)
Appears in Collections:Journal articles

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