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Please use this identifier to cite or link to this item: https://ahro.austin.org.au/austinjspui/handle/1/32070
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dc.contributor.authorKrishnadas, Natasha-
dc.contributor.authorDoré, Vincent-
dc.contributor.authorRobertson, Joanne S-
dc.contributor.authorWard, Larry-
dc.contributor.authorFowler, Christopher-
dc.contributor.authorMasters, Colin L-
dc.contributor.authorBourgeat, Pierrick-
dc.contributor.authorFripp, Jurgen-
dc.contributor.authorVillemagne, Victor L-
dc.contributor.authorRowe, Christopher C-
dc.date2023-
dc.date.accessioned2023-02-07T05:37:52Z-
dc.date.available2023-02-07T05:37:52Z-
dc.date.issued2023-01-27-
dc.identifier.citationEBioMedicine 2023; 88en_US
dc.identifier.issn2352-3964-
dc.identifier.urihttps://ahro.austin.org.au/austinjspui/handle/1/32070-
dc.description.abstractTau positron emission tomography (PET) imaging enables longitudinal observation of tau accumulation in Alzheimer's disease (AD). 18F-MK6240 is a high affinity tracer for the paired helical filaments of tau in AD, widely used in clinical trials, despite sparse longitudinal natural history data. We aimed to evaluate the natural history of tau accumulation, and the impact of disease stage and reference region on the magnitude and effect size of regional change.en_US
dc.language.isoeng-
dc.subject(18)F-MK6240en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectLongitudinalen_US
dc.subjectPositron emission tomography (PET)en_US
dc.subjectTauen_US
dc.titleRates of regional tau accumulation in ageing and across the Alzheimer's disease continuum: an AIBL 18F-MK6240 PET study.en_US
dc.typeJournal Articleen_US
dc.identifier.journaltitleEBioMedicineen_US
dc.identifier.affiliationMolecular Imaging and Therapyen_US
dc.identifier.affiliationThe Florey Institute of Neuroscience and Mental Healthen_US
dc.identifier.affiliationHealth and Biosecurity Flagship, The Australian eHealth Research Centre, Melbourne, Victoria, Australia.en_US
dc.identifier.affiliationDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.en_US
dc.identifier.doi10.1016/j.ebiom.2023.104450en_US
dc.type.contentTexten_US
dc.identifier.pubmedid36709581-
dc.description.volume88-
dc.description.startpage104450-
local.name.researcherDoré, Vincent
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.openairetypeJournal Article-
item.grantfulltextnone-
item.languageiso639-1en-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptThe Florey Institute of Neuroscience and Mental Health-
crisitem.author.deptMolecular Imaging and Therapy-
crisitem.author.deptMolecular Imaging and Therapy-
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