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Title: Therapeutic drug monitoring in oncology - What's out there: A bibliometric evaluation on the topic.
Austin Authors: Stojanova, Jana;Carland, Jane E;Murnion, Bridin;Seah, Vincent;Siderov, Jim ;Lemaitre, Florian
Affiliation: Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital, Sydney, NSW, Australia.
Université de Rennes, CHU Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), Rennes, France.
Issue Date: Nov-2022
Date: 2022
Publication information: Frontiers in Oncology 2022
Abstract: Pharmacological therapy is the mainstay of treatment for cancer patients. Despite wide interpatient variability in systemic drug concentrations for numerous antineoplastics, dosing based on body size remains the predominant approach. Therapeutic drug monitoring (TDM) is used for few antineoplastics in specific scenarios. We conducted a rapid bibliometric evaluation of TDM in oncology to capture a snapshot of research in this area over time and explore topics that reflect development in the field. Reports with the composite, indexed term 'therapeutic drug monitoring' in the title and abstract were extracted from MEDLINE (inception to August 2021). Reports related to applications in cancer were selected for inclusion and were tagged by study design, antineoplastic drugs and concepts related to TDM. We present a timeline from 1980 to the present indicating the year of first report of antineoplastic agents and key terms. The reports in our sample primarily reflected development and validation of analytical methods with few relating to clinical outcomes to support implementation. Our work emphasises evidence gaps that may contribute to poor uptake of TDM in oncology.
DOI: 10.3389/fonc.2022.959741
Journal: Frontiers in Oncology
Start page: 959741
PubMed URL: 36439413
Type: Journal Article
Subjects: antineoplastic agents
bibliometric analysis
kinase inhibitors
therapeutic drug monitoring
Appears in Collections:Journal articles

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