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Title: Cough in Idiopathic Pulmonary Fibrosis.
Austin Authors: Mann, Jennifer;Goh, Nicole S L ;Holland, Anne E ;Khor, Yet Hong
Affiliation: Central Clinical School, Monash University, Melbourne, VIC, Australia
Medicine (University of Melbourne)
Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia
Respiratory and Sleep Medicine
Institute for Breathing and Sleep
Issue Date: 2021
Date: 2021
Publication information: Frontiers in Rehabilitation Sciences 2021; 2: 751798
Abstract: Chronic cough is experienced by most patients with idiopathic pulmonary fibrosis (IPF). It is often the first symptom and is associated with reduced quality of life, increased rates of depression and anxiety, more severe physiological impairment, and disease progression. Although not fully understood, recent gains in understanding the pathophysiology of chronic cough in IPF have been made. The pathophysiology is likely multifactorial and includes alterations in mucous production and clearance, architectural distortion, and increased cough reflex sensitivity, suggesting a role for targeted therapies and multidisciplinary treatment. Modifiable comorbidities can also induce cough in patients with IPF. There is a renewed emphasis on measuring cough in IPF, with clinical trials of novel and repurposed therapies for chronic cough emerging in this population. This review provides an update on the clinical characteristics, pathophysiology, and measurement of chronic cough in patients with IPF and summarizes recent developments in non-pharmacological and pharmacological therapies.
DOI: 10.3389/fresc.2021.751798
Journal: Frontiers in Rehabilitation Sciences
PubMed URL: 36188759
Type: Journal Article
Subjects: cough
idiopathic pulmonary fibrosis
interstitial lung disease
patient reported outcome (PRO) measures
quality of life
Appears in Collections:Journal articles

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