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dc.contributor.authorMann, Jennifer-
dc.contributor.authorGoh, Nicole S L-
dc.contributor.authorHolland, Anne E-
dc.contributor.authorKhor, Yet Hong-
dc.identifier.citationFrontiers in Rehabilitation Sciences 2021; 2: 751798en
dc.description.abstractChronic cough is experienced by most patients with idiopathic pulmonary fibrosis (IPF). It is often the first symptom and is associated with reduced quality of life, increased rates of depression and anxiety, more severe physiological impairment, and disease progression. Although not fully understood, recent gains in understanding the pathophysiology of chronic cough in IPF have been made. The pathophysiology is likely multifactorial and includes alterations in mucous production and clearance, architectural distortion, and increased cough reflex sensitivity, suggesting a role for targeted therapies and multidisciplinary treatment. Modifiable comorbidities can also induce cough in patients with IPF. There is a renewed emphasis on measuring cough in IPF, with clinical trials of novel and repurposed therapies for chronic cough emerging in this population. This review provides an update on the clinical characteristics, pathophysiology, and measurement of chronic cough in patients with IPF and summarizes recent developments in non-pharmacological and pharmacological therapies.en
dc.subjectidiopathic pulmonary fibrosisen
dc.subjectinterstitial lung diseaseen
dc.subjectpatient reported outcome (PRO) measuresen
dc.subjectquality of lifeen
dc.titleCough in Idiopathic Pulmonary Fibrosis.en
dc.typeJournal Articleen
dc.identifier.journaltitleFrontiers in Rehabilitation Sciencesen
dc.identifier.affiliationCentral Clinical School, Monash University, Melbourne, VIC, Australiaen
dc.identifier.affiliationMedicine (University of Melbourne)en
dc.identifier.affiliationDepartment of Physiotherapy, Alfred Health, Melbourne, VIC, Australiaen
dc.identifier.affiliationRespiratory and Sleep Medicineen
dc.identifier.affiliationInstitute for Breathing and Sleepen
dc.identifier.pubmedid36188759-, Nicole S L
item.openairetypeJournal Article-
item.fulltextNo Fulltext-
item.languageiso639-1en- and Sleep Medicine- for Breathing and Sleep- for Breathing and Sleep-
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